Title:
PROCESS FOR PRODUCING CANTHAXANTHIN
Document Type and Number:
WIPO Patent Application WO/2003/087358
Kind Code:
A1
Abstract:
A process for producing canthaxanthin characterized by comprising mutagenizing an astaxanthin-producing microorganism the base sequence of DNA corresponding to 16S ribosomal RNA of which is substantially homologous with the base sequence represented by SEQ ID NO:1, selecting a mutant showing a ratio (% by mass) of the thus produced canthaxanthin to the total carotenoid yield higher than that of the parent strain, culturing the obtained canthaxanthin-producing strain and collecting canthaxanthin or a carotenoid mixture containing canthaxanthin from the culture medium thus obtained.
Inventors:
HIRASAWA KAZUAKI (JP)
TSUBOKURA AKIRA (JP)
MIZUTA HARUYOSHI (JP)
TSUBOKURA AKIRA (JP)
MIZUTA HARUYOSHI (JP)
Application Number:
PCT/JP2003/004398
Publication Date:
October 23, 2003
Filing Date:
April 07, 2003
Export Citation:
Assignee:
NIPPON OIL CORP (JP)
HIRASAWA KAZUAKI (JP)
TSUBOKURA AKIRA (JP)
MIZUTA HARUYOSHI (JP)
HIRASAWA KAZUAKI (JP)
TSUBOKURA AKIRA (JP)
MIZUTA HARUYOSHI (JP)
International Classes:
C12P23/00; C12N15/09; C12R1/01; (IPC1-7): C12N15/01; C12P23/00
Domestic Patent References:
| WO2001096591A1 | 2001-12-20 | |||
| WO1999006586A1 | 1999-02-11 | |||
| WO2001096591A1 | 2001-12-20 | |||
| WO1999006586A1 | 1999-02-11 |
Foreign References:
| JPH09308481A | 1997-12-02 | |||
| EP1138208A1 | 2001-10-04 | |||
| EP0872554A2 | 1998-10-21 | |||
| EP0769551A1 | 1997-04-23 | |||
| JPH02138996A | 1990-05-28 | |||
| JPH06343482A | 1994-12-20 | |||
| JP2001095500A | 2001-04-10 | |||
| EP1229126A1 | 2002-08-07 | |||
| EP1138208A1 | 2001-10-04 | |||
| JP2002112240A | 2002-04-12 |
Other References:
TSUBOKURA A. ET AL.: "Paracoccus carotinifaciens sp. nov., a new aerobic gram-negative astaxanthine-producing bacterium", INT. J. SYST. BACTERIOL., vol. 49, 1999, pages 277 - 282, XP002962170
TRINIDAD D.M. ET AL.: "Analysis of canthaxanthin and related pigments from Gordonia jacobaea mutants", J. AGRIC. FOOD CHEM., vol. 49, 2001, pages 1200 - 1202, XP002962180
NELIS H.J. ET AL.: "Reinvestigation of brevibacterium sp. strain KY-4313 as a source of canthaxanthin", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 55, no. 10, 1989, pages 2505 - 2510, XP002962181
BOTANICAL GAZETTE, vol. 112, 1950, pages 228 - 232
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 55, no. 10, 1989, pages 2505
J. AMER. CHEM. SOC., vol. 78, 1956, pages 1427
PURE APPL. CHEM., vol. 51, 1979, pages 875
MIGUEL ET AL., J AGRIC FOOD CHEM, vol. 49, 2001, pages 1200 - 1202
NELIS ET AL., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 55, no. 10, 1989, pages 2505 - 2510
See also references of EP 1496115A4
TRINIDAD D.M. ET AL.: "Analysis of canthaxanthin and related pigments from Gordonia jacobaea mutants", J. AGRIC. FOOD CHEM., vol. 49, 2001, pages 1200 - 1202, XP002962180
NELIS H.J. ET AL.: "Reinvestigation of brevibacterium sp. strain KY-4313 as a source of canthaxanthin", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 55, no. 10, 1989, pages 2505 - 2510, XP002962181
BOTANICAL GAZETTE, vol. 112, 1950, pages 228 - 232
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 55, no. 10, 1989, pages 2505
J. AMER. CHEM. SOC., vol. 78, 1956, pages 1427
PURE APPL. CHEM., vol. 51, 1979, pages 875
MIGUEL ET AL., J AGRIC FOOD CHEM, vol. 49, 2001, pages 1200 - 1202
NELIS ET AL., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 55, no. 10, 1989, pages 2505 - 2510
See also references of EP 1496115A4
Attorney, Agent or Firm:
Hiraki, Yusuke (17-1 Toranomon 1-chom, Minato-ku Tokyo, JP)
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