Title:
PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1995/001328
Kind Code:
A1
Abstract:
A process for producing a carboxylic acid derivative represented by general formula [VIII], (wherein R1, R2, R3 and L are each as defined in the specification), which comprises reacting a benzyl halide with a cyano compound to give a phenylacetonitrile, reacting the nitrile with an alkyl nitrite in the presence of a base to give an alpha-hydroxyiminophenylacetonitrile, reacting the hydroxy nitrile with an alkylating agent to give an alpha-alkoxyiminophenylacetonitrile, hydrolyzing the alkoxy nitrile in the presence of a base, optionally after hydration and acid treatment, to give an alpha-alkoxyiminophenylacetic acid, and finally reacting the acid with a halogenating agent, or converting the acid into a corresponding metal salt and reacting the salt with an alkylating agent, or reacting the acid with a lower alcohol in the presence of an acidic catalyst. According to this process, the reactions can be advanced through the respective steps under mild conditions, and the target derivative [VIII] can be produced even without resort to high-pressure steam equipment, high-temperature heat medium equipment, refrigerator, and so forth. Further, this process is advantageous in that only a single solvent will suffice without the necessity for using various solvents according to the respective steps.
Inventors:
TAKASE AKIRA (JP)
KAI HIROYUKI (JP)
MASUI MORIYASU (JP)
MASUMOTO KATUHISA (JP)
NAKAMURA AKIHIKO (JP)
KIYOSHIMA YUJIRO (JP)
SASAKI MIKIO (JP)
KAI HIROYUKI (JP)
MASUI MORIYASU (JP)
MASUMOTO KATUHISA (JP)
NAKAMURA AKIHIKO (JP)
KIYOSHIMA YUJIRO (JP)
SASAKI MIKIO (JP)
Application Number:
PCT/JP1994/001075
Publication Date:
January 12, 1995
Filing Date:
July 01, 1994
Export Citation:
Assignee:
SHIONOGI & CO (JP)
SUMITOMO CHEMICAL CO (JP)
TAKASE AKIRA (JP)
KAI HIROYUKI (JP)
MASUI MORIYASU (JP)
MASUMOTO KATUHISA (JP)
NAKAMURA AKIHIKO (JP)
KIYOSHIMA YUJIRO (JP)
SASAKI MIKIO (JP)
SUMITOMO CHEMICAL CO (JP)
TAKASE AKIRA (JP)
KAI HIROYUKI (JP)
MASUI MORIYASU (JP)
MASUMOTO KATUHISA (JP)
NAKAMURA AKIHIKO (JP)
KIYOSHIMA YUJIRO (JP)
SASAKI MIKIO (JP)
International Classes:
C07C249/12; C07C251/48; (IPC1-7): C07C251/48; C07C249/12
Foreign References:
| JPH06219986A | 1994-08-09 | |||
| JPH04288045A | 1992-10-13 |
Other References:
See also references of EP 0658541A4
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