PROCESS FOR PRODUCING CYSTEINE DERIVATIVES

Title:

PROCESS FOR PRODUCING CYSTEINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1998/030538

Kind Code:

A1

Abstract:

A process for producing cysteine derivatives having especially high optical purities economically advantageously at a high production efficiency even on an industrial scale. The process for producing cysteine derivatives represented by general formula (III) (wherein R?0� represents hydrogen or an amino-protecting group like R?1�; R?1� represents an amino-protecting group; R?2� represents a carboxyl-protecting group; and R?3� represents C�1-7? alkyl, C�6-10? aryl, or C�7-10? aralkyl) is one which comprises reacting an amino acid derivative represented by general formula (I) (wherein R?1�, R?0�, and R?2� are each as defined above; and X represents a leaving group) with a thiol compound represented by general formula (II) (wherein R?3� is as defined above), wherein the reaction is conducted in an organic raction medium in the presence of a base and water.

Inventors:

KONDO TAKESHI (JP)
NISHIYAMA AKIRA (JP)
UEYAMA NOBORU (JP)
MURAO HIROSHI (JP)
MANABE HAJIME (JP)
UEDA YASUYOSHI (JP)

Application Number:

PCT/JP1998/000101

Publication Date:

July 16, 1998

Filing Date:

January 14, 1998

Export Citation:

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Assignee:

KANEKA CORP (JP)
KONDO TAKESHI (JP)
NISHIYAMA AKIRA (JP)
UEYAMA NOBORU (JP)
MURAO HIROSHI (JP)
MANABE HAJIME (JP)
UEDA YASUYOSHI (JP)

International Classes:

C07C319/14; C07C323/58; C07C323/59; (IPC1-7): C07C323/58; B01J31/02; C07C319/14

Foreign References:

JPS60258158A	1985-12-20
JPS60258159A	1985-12-20
JPS60258161A	1985-12-20

Other References: