PROCESS FOR PRODUCING QUINAZOLIN−4−ONE DERIVATIVE

Title:

PROCESS FOR PRODUCING QUINAZOLIN−4−ONE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2003/064399

Kind Code:

A1

Abstract:

A process for producing a quinazolin−4−one derivative represented by the following formula (2): (2) (wherein R¹, R², R³, and R⁴ each represents a group not participating in the reaction and R¹, R², R³, and R⁴ may be bonded to each other to form a ring) which comprises reacting an anthranilic acid derivative represented by the following formula (1): (1) (wherein R⁵ represents hydrogen or a hydrocarbon group) with a formic acid derivative in the presence of an ammonium carboxylate.

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Inventors:

NISHINO SHIGEYOSHI (JP)
HIROTSU KENJI (JP)
SHIMA HIDETAKA (JP)
HARADA TAKASHI (JP)
ODA HIROYUKI (JP)
TAKAHASHI TAKESHI (JP)
SUZUKI SHINOBU (JP)

Application Number:

PCT/JP2003/000805

Publication Date:

August 07, 2003

Filing Date:

January 28, 2003

Export Citation:

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Assignee:

UBE INDUSTRIES (JP)
NISHINO SHIGEYOSHI (JP)
HIROTSU KENJI (JP)
SHIMA HIDETAKA (JP)
HARADA TAKASHI (JP)
ODA HIROYUKI (JP)
TAKAHASHI TAKESHI (JP)
SUZUKI SHINOBU (JP)

International Classes:

C07C201/08; C07C205/59; C07C205/60; C07C227/04; C07C229/56; C07C229/64; C07D239/88; C07D239/90; (IPC1-7): C07D239/88; C07C201/08; C07C205/60; C07C227/04; C07C229/56

Foreign References:

JP2001519788A	2001-10-23
JPH09508126A	1997-08-19

Other References:

KAMAL AHMED ET AL.: "Synthesis of novel non-cross-linking pyrrolobenzodiazepines with remarkable DNA binding affinity and potent antitumour activity", CHEMICAL COMMUNICATIONS, no. 5, 2001, CAMBRIDGE, UNITED KINGDOM, pages 437 - 438, XP002963782
BOSCHELLI DIANE H. ET AL.: "Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 23, 2001, pages 3965 - 3977, XP001105608
See also references of EP 1477481A4

Attorney, Agent or Firm:

Yanagawa, Yasuo (2-14 Yotsuy, Shinjuku-ku Tokyo, JP)

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