Title:
PROCESS FOR PRODUCING ENZALUTAMIDE CRYSTAL FORM
Document Type and Number:
WIPO Patent Application WO/2016/194813
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a new process for producing an enzalutamide crystal form which is reduced in the contents of 2-propanol and B-form crystals, the process including obtaining wet crystals of enzalutamide in a crystallization step during the production of the enzalutamide crystal form and subsequently subjecting the enzalutamide to solvation. The present invention relates to a process for producing an enzalutamide crystal form, characterized by including a crystallization step in which wet crystals of enzalutamide are obtained and a step for drying the wet crystals and by including, after the crystallization step, a cleaning step in which a solvent mixture of a good solvent and a poor solvent is used.
Inventors:
SUZUKI YUSUKE (JP)
NAKAGAWA SHUICHI (JP)
KITAMURA TSUYOSHI (JP)
NAKAGAWA SHUICHI (JP)
KITAMURA TSUYOSHI (JP)
Application Number:
PCT/JP2016/065729
Publication Date:
December 08, 2016
Filing Date:
May 27, 2016
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C07D233/86; C07C331/28
Domestic Patent References:
| WO2014041487A2 | 2014-03-20 | |||
| WO2016005875A1 | 2016-01-14 |
Other References:
See also references of EP 3305770A4
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P. C. (JP)
Patent business corporation glory patent firm (JP)
Patent business corporation glory patent firm (JP)
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