Title:
PROCESS FOR PRODUCING KETOPROFEN AND 5-BENZOYL-3-METHYL-2-INDOLINONE
Document Type and Number:
WIPO Patent Application WO/1998/049127
Kind Code:
A1
Abstract:
A process for producing ketoprofen by benzoylating 3-methyl-2-indolinone with a benzoyl halide, cleaving the amido bond forming the five-membered ring moiety of the formed 5-benzoyl-3-methyl-2-indolinone with a basic compound and replacing an aromatic amino group of the formed compound with a hydrogen atom. A very high yield of ketoprofen can be obtained through ordinary steps, which are short as a whole, without using chemicals of an extremely high toxicity such as cyanides or chemicals of a low handleability, such as liquid ammonia.
Inventors:
KONDO HISAO (JP)
HIGASHIKAWA TETSURO (JP)
KUBO AKINARI (JP)
SAITO NAOKI (JP)
HIGASHIKAWA TETSURO (JP)
KUBO AKINARI (JP)
SAITO NAOKI (JP)
Application Number:
PCT/JP1998/001939
Publication Date:
November 05, 1998
Filing Date:
April 28, 1998
Export Citation:
Assignee:
MEDICAL INFORMATION SERVICES I (JP)
KONDO HISAO (JP)
HIGASHIKAWA TETSURO (JP)
KUBO AKINARI (JP)
SAITO NAOKI (JP)
KONDO HISAO (JP)
HIGASHIKAWA TETSURO (JP)
KUBO AKINARI (JP)
SAITO NAOKI (JP)
International Classes:
C07D209/34; (IPC1-7): C07C59/84; C07C51/06; C07C51/377; C07D209/34
Foreign References:
| JPS4941349A | 1974-04-18 | |||
| JPS5223052A | 1977-02-21 | |||
| JPS6399024A | 1988-04-30 | |||
| JPS6466144A | 1989-03-13 |
Other References:
See also references of EP 0990637A4
Attorney, Agent or Firm:
Takino, Hideo (4th floor 36-13, Ebisu 2-chom, Shibuya-ku Tokyo, JP)
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