Title:
PROCESS FOR PRODUCING MENAQUINONE-4
Document Type and Number:
WIPO Patent Application WO/2010/053077
Kind Code:
A1
Abstract:
A process for producing menaquinone-4, which is characterized by culturing a microorganism having an increased dehydroxynaphthoate prenyltransferase activity compared with that of a wild-type one in a culture medium to produce and accumulate menaquinone-4 in a culture and collecting menaquinone-4 from the culture.
Inventors:
UJIHARA TETSURO
MIYAKE KOICHIRO
YAGASAKI MAKOTO
MIYAKE KOICHIRO
YAGASAKI MAKOTO
Application Number:
PCT/JP2009/068790
Publication Date:
May 14, 2010
Filing Date:
November 04, 2009
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
UJIHARA TETSURO
MIYAKE KOICHIRO
YAGASAKI MAKOTO
UJIHARA TETSURO
MIYAKE KOICHIRO
YAGASAKI MAKOTO
International Classes:
C12P7/66; C12N15/09
Foreign References:
| JPS61265097A | 1986-11-22 | |||
| JPS61216696A | 1986-09-26 |
Other References:
SUVARNA D. ET AL.: "Menaquinone (Vitamin K2) Biosynthesis: Localization and Characterization of the menA Gene from Escherichia coli.", J. BACTERIOL., vol. 180, no. 10, 1998, pages 2782 - 2787
SHINEBERG D. ET AL.: "Biosynthesis of bacterial menaquinones: the membrane-associated 1, 4- dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli.", BIOCHEMISTRY, vol. 15, no. 13, 1976, pages 2754 - 2758
WARD M. J. ET AL.: "A derivative of the menaquinone precursor 1, 4-dihydroxy-2- naphthoate is involved in the reductive transformation of carbon tetrachloride by aerobically grown Shewanella oneidensis MR-1.", APPL. MICROBIOL. BIOTECHNOL., vol. 63, 2004, pages 571 - 577
SHINEBERG D. ET AL.: "Biosynthesis of bacterial menaquinones: the membrane-associated 1, 4- dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli.", BIOCHEMISTRY, vol. 15, no. 13, 1976, pages 2754 - 2758
WARD M. J. ET AL.: "A derivative of the menaquinone precursor 1, 4-dihydroxy-2- naphthoate is involved in the reductive transformation of carbon tetrachloride by aerobically grown Shewanella oneidensis MR-1.", APPL. MICROBIOL. BIOTECHNOL., vol. 63, 2004, pages 571 - 577
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