Title:
PROCESS FOR PRODUCING NAFAMOSTAT MESYLATE
Document Type and Number:
WIPO Patent Application WO/2014/007326
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a process for producing nafamostat mesylate without via nafamostat bicarbonate and while avoiding inclusion of sodium mesylate.
The process for producing nafamostat mesylate comprises (1) a step in which an anion-exchange resin in which the anion is a mesylic acid ion is prepared, (2) a step in which the anion-exchange resin obtained in the step (1) is brought into contact with a nafamostat salt which is neither nafamostat bicarbonate nor nafamostat mesylate, in the presence of a solvent to thereby convert the nafamostat salt into nafamostat mesylate by salt exchange, and (3) a step in which the nafamostat mesylate obtained in the step (2) is crystallized.
Inventors:
YAMANAKA NOBUHIRO (JP)
YOSHIZAKI HIROAKI (JP)
MATSUZAWA TOSHIHIRO (JP)
YOSHIZAKI HIROAKI (JP)
MATSUZAWA TOSHIHIRO (JP)
Application Number:
PCT/JP2013/068360
Publication Date:
January 09, 2014
Filing Date:
July 04, 2013
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C07C277/06; C07C279/18
Foreign References:
| JPH0672981A | 1994-03-15 |
Other References:
AOYAMA T. ET AL.: "Synthesis and Structure- Activity Study of Protease Inhibitors. IV. Amidinonaphthols and Related Acyl Derivatives", CHEM. PHARM. BULL., vol. 33, no. 4, 1985, pages 1458 - 1471
Attorney, Agent or Firm:
TSUJII Koichi et al. (JP)
辻居 Koichi (JP)
辻居 Koichi (JP)
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