Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HALO-1,2-PROPANEDIOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2003/070676
Kind Code:
A1
Abstract:
A process for easily producing from an inexpensive material an optically active 3-halo-1,2-propanediol derivative useful as an intermediate for medicines. The process comprises reacting 2-chloroallyl alcohol, which is easily available at low cost, with a hypohalogenous acid salt or a halogen to convert the alcohol into a halohydroxyacetone derivative and subsequently asymmetrically hydrogenating the halohydroxyacetone derivative with hydrogen and an asymmetric hydrogenation catalyst prepared from a transition metal and an optically active phosphine ligand to thereby produce an optically active 3-halo-1,2-propanediol derivative.
Inventors:
TAOKA NAOAKI (JP)
SUGAWARA MASANOBU (JP)
YASOHARA YOSHIHIKO (JP)
SUGAWARA MASANOBU (JP)
YASOHARA YOSHIHIKO (JP)
Application Number:
PCT/JP2003/001962
Publication Date:
August 28, 2003
Filing Date:
February 24, 2003
Export Citation:
Assignee:
KANEKA CORP (JP)
TAOKA NAOAKI (JP)
SUGAWARA MASANOBU (JP)
YASOHARA YOSHIHIKO (JP)
TAOKA NAOAKI (JP)
SUGAWARA MASANOBU (JP)
YASOHARA YOSHIHIKO (JP)
International Classes:
C07B53/00; C07B61/00; C07C29/145; C07C31/42; C07C45/00; C07C45/30; C07C45/81; C07C49/173; C07D319/12; (IPC1-7): C07C45/30; C07B53/00; C07B61/00; C07C29/145; C07C31/42; C07C49/173; C07D319/12
Domestic Patent References:
| WO2003018523A1 | 2003-03-06 |
Foreign References:
| EP0295890A2 | 1988-12-21 | |||
| EP0339764A1 | 1989-11-02 | |||
| EP0592881A2 | 1994-04-20 | |||
| EP0831099A2 | 1998-03-25 | |||
| US2285329A | 1942-06-02 |
Other References:
MEISTER H.: "Darstellung und Hydrolyse von 4-Halogenmethylen-1,3-dioxolanen", LIEBIGS ANN. CHEM., vol. 724, 1969, pages 128 - 136, XP002960494
WILLIAMS D.L.H.: "Possible nucleophilic addition accompanying electrophilic addition in the reaction of hypochlorous acid with 2,3-dichloropropene", J. ORG. CHEM. (B), 1969, pages 421 - 426, XP002969913
WILLIAMS D.L.H.: "Possible nucleophilic addition accompanying electrophilic addition in the reaction of hypochlorous acid with 2,3-dichloropropene", J. ORG. CHEM. (B), 1969, pages 421 - 426, XP002969913
Attorney, Agent or Firm:
Yasutomi, Yasuo (4-20 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, JP)
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