Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE 7−&lcub 2−CYCLOPROPYL−4−&lpar 4−FLUOROPHENYL&rpar QUINOLIN−3−YL&rcub −3,5−DIHYDROXYHEPT−6−ENOIC ACID ESTER
Document Type and Number:
WIPO Patent Application WO/2003/027073
Kind Code:
A1
Abstract:
A (3R,5S)−7−&lcub 2−cyclopropyl−4−(4−fluorophenyl)quinolin−3−yl&rcub −3,5−dihydroxyhept−6−enoic acid ester useful as an intermediate for an HMG−CoA reductase inhibitor (cholesterol−lowering agent) can be obtained in a high yield by a method in which a salt of (3R,5S)−7−&lcub 2−cyclopropyl−4−(4−fluorophenyl)quinolin−3−yl&rcub −3,5−dihydroxyhept−6−enoic acid with an amine is reacted with an alcohol in a solvent in the presence of an acid or by a method comprising reacting the salt with an esterifying agent in a solvent in the presence of a base.
Inventors:
NISHINO SHIGEYOSHI (JP)
MATSUSHITA AKIO (JP)
YOKOYAMA SHUJI (JP)
KAWACHI YASUHIRO (JP)
SASAKI HIROSHI (JP)
MATSUSHITA AKIO (JP)
YOKOYAMA SHUJI (JP)
KAWACHI YASUHIRO (JP)
SASAKI HIROSHI (JP)
Application Number:
PCT/JP2002/009638
Publication Date:
April 03, 2003
Filing Date:
September 19, 2002
Export Citation:
Assignee:
UBE INDUSTRIES (JP)
NISHINO SHIGEYOSHI (JP)
MATSUSHITA AKIO (JP)
YOKOYAMA SHUJI (JP)
KAWACHI YASUHIRO (JP)
SASAKI HIROSHI (JP)
NISHINO SHIGEYOSHI (JP)
MATSUSHITA AKIO (JP)
YOKOYAMA SHUJI (JP)
KAWACHI YASUHIRO (JP)
SASAKI HIROSHI (JP)
International Classes:
C07D215/14; (IPC1-7): C07D215/14
Foreign References:
| EP0520406A1 | 1992-12-30 | |||
| JPH0892217A | 1996-04-09 |
Other References:
SUZUKI MIKIO ET AL.: "First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 20, 1999, pages 2977 - 2982, XP004180521
Attorney, Agent or Firm:
Yanagawa, Yasuo (2-14 Yotsuy, Shinjuku-ku Tokyo, JP)
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