Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL AND CARBOXYLIC ACID
Document Type and Number:
WIPO Patent Application WO/2005/075651
Kind Code:
A1
Abstract:
A low-cost and efficient industrial process for producing (S)-2-pentanol, (S)-2-hexanol, 1-methylalkylmalonic acid and 3-methylcarboxylic acid with high optical purity. There is provided a process for producing (S)-2-pentanol and (S)-2-hexanol, comprising causing a certain type of microbe or transformed cells, a treatment mixture from the microbe or cells, a culture solution of the microbe or cells and/or a product of crude purification or purification of a carbonyl reductase fraction obtained from the microbe or cells to act on 2-pentanone and 2-hexanone, respectively.
Inventors:
DEKISHIMA YASUKATA (JP)
KAWABATA HIROSHI (JP)
HIRAOKA HIROTOSHI (JP)
UEDA MAKOTO (JP)
UEHARA HISATOSHI (JP)
KAWABATA HIROSHI (JP)
HIRAOKA HIROTOSHI (JP)
UEDA MAKOTO (JP)
UEHARA HISATOSHI (JP)
Application Number:
PCT/JP2005/002093
Publication Date:
August 18, 2005
Filing Date:
February 04, 2005
Export Citation:
Assignee:
API CORP (JP)
DEKISHIMA YASUKATA (JP)
KAWABATA HIROSHI (JP)
HIRAOKA HIROTOSHI (JP)
UEDA MAKOTO (JP)
UEHARA HISATOSHI (JP)
DEKISHIMA YASUKATA (JP)
KAWABATA HIROSHI (JP)
HIRAOKA HIROTOSHI (JP)
UEDA MAKOTO (JP)
UEHARA HISATOSHI (JP)
International Classes:
C07C51/00; C07C55/08; C07C67/343; C07C303/28; C12N15/53; C12P7/04; C12P7/40; C12P7/44; C07C309/66; (IPC1-7): C12N15/53; C07C55/08; C12P7/04; C12P7/40; C12P7/44
Foreign References:
| JP2005006552A | 2005-01-13 | |||
| JP2005000002A | 2005-01-06 |
Other References:
XIE S.X. ET AL: "NAD(+)-dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2-ol catalyzed by Nocardia fusca AKU 2123", BIOSCI BIOTECHNOL BIOCHEM, vol. 63, no. 10, 1999, pages 1721 - 1729, XP009039491
GROEGER H. ET AL: "Preparative asymmetric reduction of ketones in a biphasic medium with an (S)-alcohol dehydrogenase under in situ-cofactor-recycling with a formate dehydrogenase", TERTAHEDRON, vol. 60, no. 3, 12 January 2004 (2004-01-12), pages 633 - 640, XP004482876
HUMMEL W. ET AL: "Towards a Large-scale Asymmetric Reduction Process with Isolated Enzymes: Expression of an (S)-Alcohol Dehydrogenase in E. coli, and Studies on the Synthetic Potential of this Biocatalyst", ADV SYNTH CATAL, vol. 345, no. 1-2, 2003, pages 153 - 159, XP002988731
See also references of EP 1712630A4
GROEGER H. ET AL: "Preparative asymmetric reduction of ketones in a biphasic medium with an (S)-alcohol dehydrogenase under in situ-cofactor-recycling with a formate dehydrogenase", TERTAHEDRON, vol. 60, no. 3, 12 January 2004 (2004-01-12), pages 633 - 640, XP004482876
HUMMEL W. ET AL: "Towards a Large-scale Asymmetric Reduction Process with Isolated Enzymes: Expression of an (S)-Alcohol Dehydrogenase in E. coli, and Studies on the Synthetic Potential of this Biocatalyst", ADV SYNTH CATAL, vol. 345, no. 1-2, 2003, pages 153 - 159, XP002988731
See also references of EP 1712630A4
Attorney, Agent or Firm:
SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
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