Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE ERYTHRO 3-CYCLOHEXYLSERINES
Document Type and Number:
WIPO Patent Application WO/2004/024934
Kind Code:
A1
Abstract:
A process which comprises asymmetrically hydrolyzing an N-acylated DL-erythro 3-substituted serine represented by the following general formula (1): (1) (wherein R1 represents C1-10 alkanoyl, benzoyl, C1-5 alkanoyl substituted by halogeno, or benzoyl substituted by halogeno; and R2 means phenyl or cyclohexyl) with L-aminoacylase or D-aminoacylase to obtain an N-acylated D-erythro 3-substituted serine in an unreacted form or a hydrolyzed D-erythro 3-substituted serine, respectively. The D-erythro compounds are useful as an intermediate for medicines, e.g., a drug known to be useful as, e.g., an anti-HIV drug (WO 01/40227).
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Inventors:
IKEO TAKAYOSHI (JP)
Application Number:
PCT/JP2003/011390
Publication Date:
March 25, 2004
Filing Date:
September 05, 2003
Export Citation:
Assignee:
NIPPON KAYAKU KK (JP)
YAMAMOTO KEN ICHI (JP)
IKEO TAKAYOSHI (JP)
YAMAMOTO KEN ICHI (JP)
IKEO TAKAYOSHI (JP)
International Classes:
C07B53/00; C07B61/00; C07C227/20; C07C229/28; C07C233/47; C12N9/80; C12P13/06; C12P41/00; (IPC1-7): C12P41/00; C07C227/30; C07C227/20; C07C229/28; C07C269/06; C07C271/22; C07C233/47
Foreign References:
| EP0141613A2 | 1985-05-15 | |||
| JPS5542534A | 1980-03-25 | |||
| JPH06165693A | 1994-06-14 | |||
| JPH02207793A | 1990-08-17 | |||
| JPH04257536A | 1992-09-11 |
Other References:
INOUE, HIROZUMI ET AL.: "A New Eniantioselective Synthesis of (2R,3S9-3-(4-Methoxyphenyl) glycidic Ester via the Enzymatic Hydrolysis of erythro-N-Acetyl-Beta-(4-methoxyphenyl)serine", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 41, no. 9, 1993, pages 1521 - 1523, XP002102485
SOLOSHONOK, V ET AL.: "Asymmetric of organoelent analogs of natural compounds. III. Biocatalytic methodfor the preparation of homochiral fluoride-subsituted (R)- and (S)-phenyllalanines and (S,R)- and (R,S)- phenylserines.", BIOORGANICHESKAYA KHIMIYA, vol. 19, no. 4, 1993, pages 478 - 483, XP002974937
SOLOSHONOK, V ET AL.: "Asymmetric of organoelent analogs of natural compounds. III. Biocatalytic methodfor the preparation of homochiral fluoride-subsituted (R)- and (S)-phenyllalanines and (S,R)- and (R,S)- phenylserines.", BIOORGANICHESKAYA KHIMIYA, vol. 19, no. 4, 1993, pages 478 - 483, XP002974937
Attorney, Agent or Firm:
Saeki, Norio (Aminosan Kaikan Building 15-8, Nihonbashi 3-chom, Chuo-ku Tokyo, JP)
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