PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL-2-PIPERAZINECARBOXAMIDE AND METHOD OF RACEMIZING THE AMIDE

WIPO Patent Application WO/1995/029170

A1

A process for producing optically active N-tert-butyl-2-piperazinecarboxamide useful as, for example, an intermediate for medicines at a high optical purity by the optical resolution of (R,S)-N-tert-butyl-2-piperazinecarboxyamide with the use of optically active lactic, malic or tartaric acid. The antipode remaining as a useless antipode in the above optical resolution step can be used effectively by racemizing optically active N-tert-butyl-2-piperazinecarboxamide in the presence of a basic compound and effecting optical resolution again.

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WATANABE NANAO (JP)
TOKUDA YOKO (JP)
KIKEGAWA KENICHI (JP)
KURANISHI HIDEKI (JP)
KURAHASHI TAKASHI (JP)

PCT/JP1995/000777

November 02, 1995

April 20, 1995

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KOEI CHEMICAL CO (JP)
WATANABE NANAO (JP)
TOKUDA YOKO (JP)
KIKEGAWA KENICHI (JP)
KURANISHI HIDEKI (JP)
KURAHASHI TAKASHI (JP)

C07D241/04; (IPC1-7): C07D241/04

JPH01117869A	1989-05-10
JPH03279375A	1991-12-10
JPS49110830A	1974-10-22
JPH05279337A	1993-10-26
JPS51146487A	1976-12-16

TETSUO SHIBA (STEREOCHEMISTRY) 1st EDIT., Kagakudojin Co. Ltd., 3rd line from the bottom, page 42 to line 1, page 43.
TANEZO TAGUCHI (INTRODUCTION TO STEREOCHEMISTRY) REV. 2nd EDIT., Nanzando K.K., (1961), Line 10, page 88 to line 7, page 89.
See also references of EP 0705824A4

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