Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE PHENYLPROPYLAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/004093
Kind Code:
A1
Abstract:
A process for industrially advantageously producing tamsulosin or a pharmacologically acceptable salt thereof, which are useful as a therapeutic agent for urination disorders accompanying prostatic hypertrophy. The process, which is for producing tamsulosin or a pharmacologically acceptable salt thereof, is characterized by asymmetrically reducing the compound represented by the formula [Chemical formula 1] (III) to obtain a phenylpropylamine derivative in which the (R) isomer is in excess, converting it into a diastereomeric salt with (R)-mandelic acid, purifying the salt by recrystallization to obtain the diastereomeric salt represented by the formula [Chemical formula 2] (V) and then decomposing the diastereomeric salt and, if necessary, converting the resultant reaction product into a pharmacologically acceptable salt thereof.
Inventors:
MAEDA SADAYUKI (JP)
Application Number:
PCT/JP2005/012346
Publication Date:
January 12, 2006
Filing Date:
July 04, 2005
Export Citation:
Assignee:
HAMARI CHEMICALS LTD (JP)
MAEDA SADAYUKI (JP)
MAEDA SADAYUKI (JP)
International Classes:
C07B53/00; C07B57/00; C07C303/40; C07C303/44; C07C311/37; C07C59/50; C07F15/00; (IPC1-7): C07C303/44; C07B53/00; C07B57/00; C07B61/00; C07C59/50; C07C303/40; C07C311/37; C07F15/00
Domestic Patent References:
| WO2003097571A1 | 2003-11-27 |
Foreign References:
| CZ293922B6 | 2004-08-18 | |||
| EP1449829A1 | 2004-08-25 | |||
| JPH066565B2 | 1994-01-26 | |||
| JPS6252742B2 | 1987-11-06 | |||
| JPH0137391B2 | 1989-08-07 | |||
| JP2004522732A | 2004-07-29 |
Other References:
ZHOU Y.B. ET AL: "Chiral 1,2,3,4-tetrahydroquinolinyl-oxazoline ligands for Ru-catalyzed asymmetric transfer hydrogenation of ketones.", TETRAHEDRON ASYMMETRY., vol. 13, 2002, pages 469 - 473, XP004349470
Attorney, Agent or Firm:
Iwatani, Ryo (1-31 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, JP)
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