PROCESS FOR PRODUCING OPTICALLY ACTIVE THREO-3-AMINO-1,2-EPOXY COMPOUNDS

Title:

PROCESS FOR PRODUCING OPTICALLY ACTIVE THREO-3-AMINO-1,2-EPOXY COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/1999/038855

Kind Code:

A1

Abstract:

Highly pure optically active threo-3-amino-1,2-epoxy compounds appropriate for materials for manufacturing drugs and a process for producing the same on an industrial scale. An optically active threo-3-amino-1,2-diol derivative is subjected in an organic solvent in the presence of a base to alkylsulfonylation or arylsulfonation to thereby give the corresponding optically active threo-3-amino-2-hydroxy-1-sulfonyloxy compound. Next, the resultant product is subjected to epoxidation in the presence of a base to give the corresponding optically active threo-3-amino-1,2-epoxy compound. The thus obtained epoxy compound is purified by using an organic solvent and water, thus giving a highly pure epoxy compound.

Inventors:

SAGAWA YUKIHIRO (JP)
SEKINE JOUJI (JP)
SATO HISAO (JP)

Application Number:

PCT/JP1999/000091

Publication Date:

August 05, 1999

Filing Date:

January 13, 1999

Export Citation:

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Assignee:

NIPPON KAYAKU KK (JP)
SAGAWA YUKIHIRO (JP)
SEKINE JOUJI (JP)
SATO HISAO (JP)

International Classes:

C07C303/28; C07D303/36; C07C309/66; (IPC1-7): C07D301/02

Foreign References:

JPH07215955A	1995-08-15
JPH08225557A	1996-09-03
JPH03251577A	1991-11-11

Other References: