Title:
PROCESS FOR PRODUCING PENAM COMPOUND
Document Type and Number:
WIPO Patent Application WO/2006/046539
Kind Code:
A1
Abstract:
An industrially advantageous process for efficiently producing a 2&agr -methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3&agr carboxylic acid ester as the target compound while significantly inhibiting an undesirable cepham compound from generating as a by-product. Diphenylmethyl 2β-bromomethyl-2&agr -methylpenam-3&agr -carboxylate (BMPB) is reacted with 1,2,3-triazole in a halogenated hydrocarbon at -5°C or lower. By conducting the reaction in a halogenated hydrocarbon at -5°C or lower, the generation of an undesirable cepham compound as a by-product can be significantly inhibited, whereby the target diphenylmethyl 2&agr -methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3&agr carboxylate (TMPB) can be efficiently produced.
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Inventors:
WADA ISAO (JP)
TOKUMARU YOSHIHISA (JP)
SHIMABAYASHI AKIHIRO (JP)
TOKUMARU YOSHIHISA (JP)
SHIMABAYASHI AKIHIRO (JP)
Application Number:
PCT/JP2005/019559
Publication Date:
May 04, 2006
Filing Date:
October 25, 2005
Export Citation:
Assignee:
OTSUKA CHEMICAL CO LTD (JP)
WADA ISAO (JP)
TOKUMARU YOSHIHISA (JP)
SHIMABAYASHI AKIHIRO (JP)
WADA ISAO (JP)
TOKUMARU YOSHIHISA (JP)
SHIMABAYASHI AKIHIRO (JP)
International Classes:
C07D499/04; C07B53/00
Foreign References:
| JPS63264486A | 1988-11-01 | |||
| JPS4969694A | 1974-07-05 |
Other References:
YONG D ET AL: "Sythetic Process of Tazobactam, Beta-lactamase inhibitor.", CHINESE JOURNAL OF MEDICINE CHEMISTRY., vol. 11, no. 2, April 2001 (2001-04-01), pages 93 - 95, XP009132599
Attorney, Agent or Firm:
Saegusa, Eiji (1-7-1 Doshomach, Chuo-ku Osaka-shi Osaka 45, JP)
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