Title:
PROCESS FOR PRODUCING (R)-2-HYDROXY-1-PHENOXYPROPANE DERIVATIVE WHILE PREVENTING THE FORMATION OF TRANSFER BY- PRODUCT
Document Type and Number:
WIPO Patent Application WO/2002/079485
Kind Code:
A1
Abstract:
It is intended to provide a process for efficiently producing an (R)-2-hydroxy-1-phenoxypropane derivative with high qualities, which is highly useful as a drug intermediate, from an inexpensive material. A (R)-2-hydroxy-1-phenoxypropane derivative with high qualities is produced by a reaction of R-selectively reducing a phenoxyacetone derivative, which is an inexpensive material, with the use of a microorganism-origin enzyme or an optionally processed culture of a microorganism capable of producing this enzyme while controlling the reaction pH value, temperature conditions, etc. so as to prevent the formation of an (R)-1-hydroxy-2-phenoxypropane derivative as a by-product.
Inventors:
KAWANO SHIGERU (JP)
HORIKAWA MIHO (JP)
TAOKA NAOAKI (JP)
YASOHARA YOSHIHIKO (JP)
HORIKAWA MIHO (JP)
TAOKA NAOAKI (JP)
YASOHARA YOSHIHIKO (JP)
Application Number:
PCT/JP2002/003138
Publication Date:
October 10, 2002
Filing Date:
March 29, 2002
Export Citation:
Assignee:
KANEKA CORP (JP)
UEDA MAKOTO (JP)
KAWANO SHIGERU (JP)
HORIKAWA MIHO (JP)
TAOKA NAOAKI (JP)
YASOHARA YOSHIHIKO (JP)
UEDA MAKOTO (JP)
KAWANO SHIGERU (JP)
HORIKAWA MIHO (JP)
TAOKA NAOAKI (JP)
YASOHARA YOSHIHIKO (JP)
International Classes:
C12P7/22; C12R1/19; (IPC1-7): C12P7/22
Domestic Patent References:
| WO2000037666A1 | 2000-06-29 |
Foreign References:
| JPH03183489A | 1991-08-09 | |||
| JPH0568577A | 1993-03-23 | |||
| JP2002085085A | 2002-03-26 | |||
| JPH04267890A | 1992-09-24 |
Attorney, Agent or Firm:
Yasutomi, Yasuo (4-20 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, JP)
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