Title:
PROCESS FOR PRODUCING RADIOACTIVE-FLUORINE-LABELED COMPOUND
Document Type and Number:
WIPO Patent Application WO/2005/044758
Kind Code:
A1
Abstract:
An on-column process by which various radioactive-fluorine-labeled compounds can be obtained in a high yield. The process comprises a step in which [18O]water containing [18F]fluoride ions is introduced into a column packed with an anion-exchange resin for labeled-compound synthesis to collect the [18F]fluoride ions, a step in which the column is dehydrated, and a step in which a substrate is introduced into the column to cause a displacement reaction between the [18F]fluoride ions collected in the column and a leaving group of the substrate to thereby obtain a radioactive-fluorine-labeled compound, wherein the step of passing carbon dioxide through the column is conducted between the column hydration step and the substrate introduction step.
Inventors:
HIRANO KEIICHI (JP)
Application Number:
PCT/JP2004/016533
Publication Date:
May 19, 2005
Filing Date:
November 08, 2004
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
HIRANO KEIICHI (JP)
HIRANO KEIICHI (JP)
International Classes:
C07B59/00; C07H5/02; C07H13/06; (IPC1-7): C07B59/00; C07H5/02; C07H13/06; G21H5/02
Foreign References:
| JPH08325168A | 1996-12-10 | |||
| JPH08325169A | 1996-12-10 | |||
| JPH09263594A | 1997-10-07 | |||
| JPH09263591A | 1997-10-07 |
Other References:
See also references of EP 1683776A4
Attorney, Agent or Firm:
Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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