Title:
PROCESS FOR PRODUCING SOLIFENACIN OR ITS SALT
Document Type and Number:
WIPO Patent Application WO/2005/105795
Kind Code:
A1
Abstract:
A novel process for producing solifenacin or its salt that is useful as a medicine, especially a therapeutic agent and/or preventive agent for urinary diseases, such as frequent urination and involuntary urination. In particular, there are provided (1) a process for producing solifenacin from 2-(imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline as a production starting material; (2) a process for producing solifenacin succinate from quinuclidinyl (1RS)-phenyltetrahydroisoquinolinecarboxylate as a production starting material; (3) a process for producing solifenacin from a lower-alkylquinuclidinyl carbonate as a production starting material; and (4) a process for producing solifenacin, comprising causing an alkali metal lower alkoxide to act on a secondary lower alkyl or tertiary lower alkyl phenyltetrahydroisoquinolinecarboxylate as a production starting material.
Inventors:
INAKOSHI MASATOSHI (JP)
ISHII YUSUKE (JP)
ISHII YUSUKE (JP)
Application Number:
PCT/JP2005/007771
Publication Date:
November 10, 2005
Filing Date:
April 25, 2005
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
INAKOSHI MASATOSHI (JP)
ISHII YUSUKE (JP)
INAKOSHI MASATOSHI (JP)
ISHII YUSUKE (JP)
International Classes:
C07D453/02; (IPC1-7): C07D453/02
Domestic Patent References:
| WO1996020194A1 | 1996-07-04 |
Other References:
See also references of EP 1757604A4
None
None
Attorney, Agent or Firm:
Morita, Hiroshi c/o Astellas Pharma Inc. (Intellectual Property 3-11, Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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