PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BEZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS

WIPO Patent Application WO/2007/097279

A1

Disclosed is a production process using, as an intermediate, a 6-(halomethyl)-1,2-benzisooxazol-3(2H)-one derivative represented by the general formula: Wherein R5 represents a methyl group substituted by at least one phenyl group which may be substituted, or an oxygenated heterocyclic ring which may be substituted; and X represents a halogen atom. The process is useful for the production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid, which is useful as an antirheumatic agent, in a high yield and in a safe and simple manner.

JPS6393757	DIAMINE COMPOUND, MANUFACTURE AND ANALGESIC
WO/2006/116615	BENZISOXAZOLE PIPERAZINE COMPOUNDS AND METHODS OF USE THEREOF
JP2003528071	[Title of Invention] Composition and method for treating Alzheimer's disease

YONEZAWA KENJI (JP)
TAKAMATSU TAMOTSU (JP)
AOKI NAOKATU (JP)
HASHIMOTO TOMOHIRO (JP)
TAKEBAYASHI MASAHIRO (JP)
SUZUKI YOSHIAKI (JP)
OONISHI YUJI (JP)

PCT/JP2007/052953

August 30, 2007

February 19, 2007

Click for automatic bibliography generation  

TOYAMA CHEMICAL CO LTD (JP)
YONEZAWA KENJI (JP)
TAKAMATSU TAMOTSU (JP)
AOKI NAOKATU (JP)
HASHIMOTO TOMOHIRO (JP)
TAKEBAYASHI MASAHIRO (JP)
SUZUKI YOSHIAKI (JP)
OONISHI YUJI (JP)

C07D261/20; C07C67/303; C07C69/738; C07D311/14; C07B61/00

WO2003042150A1	2003-05-22
WO2000027792A1	2000-05-18

GOTTLIEB H.E. ET AL.: "13C nuclear magnetic resonance spectroscopy of 6- and 7-substituted coumarins. Correlation with Hammett constants", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, no. 4, 1979, pages 435 - 437, XP003017323
See also references of EP 1988085A4

View/Download PDF      PDF Help

Previous Patent: SEAL MEMBER FOR DOOR

Next Patent: DISPLAY CONTROL DEVICE, DISPLAY CONTROL METHOD, AND DISPLAY CONTROL PROGRAM