Title:
PROCESS FOR PRODUCTION OF CINNAMAMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/058305
Kind Code:
A1
Abstract:
A compound (8) represented by the formula: (8) [wherein R1 represents a
6- to 14-membered aromatic hydrocarbon ring group which may have a substituent; and
n represents 0 to 2] can be produced with good efficiency by reacting a compound (1)
represented by the formula: (3) [wherein R1 and n are as defined above;
and Q represents a single bond or -CH(Y)- where Y represents a hydrogen atom or
a C1-6 alkyl group] with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in
the presence of a base.
Inventors:
SHIMOMURA NAOYUKI (JP)
SATO NOBUAKI (JP)
KANEKO TOSHIHIKO (JP)
TAKAISHI MAMORU (JP)
WAKASUGI KAZUNORI (JP)
YOSHIKAWA SEIJI (JP)
NISHIKAWA YOSHIHIRO (JP)
NAKAMURA TAIJU (JP)
HUKUYAMA TOHORU (JP)
SATO NOBUAKI (JP)
KANEKO TOSHIHIKO (JP)
TAKAISHI MAMORU (JP)
WAKASUGI KAZUNORI (JP)
YOSHIKAWA SEIJI (JP)
NISHIKAWA YOSHIHIRO (JP)
NAKAMURA TAIJU (JP)
HUKUYAMA TOHORU (JP)
Application Number:
PCT/JP2006/322982
Publication Date:
May 24, 2007
Filing Date:
November 17, 2006
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
SHIMOMURA NAOYUKI (JP)
SATO NOBUAKI (JP)
KANEKO TOSHIHIKO (JP)
TAKAISHI MAMORU (JP)
WAKASUGI KAZUNORI (JP)
YOSHIKAWA SEIJI (JP)
NISHIKAWA YOSHIHIRO (JP)
NAKAMURA TAIJU (JP)
HUKUYAMA TOHORU (JP)
SHIMOMURA NAOYUKI (JP)
SATO NOBUAKI (JP)
KANEKO TOSHIHIKO (JP)
TAKAISHI MAMORU (JP)
WAKASUGI KAZUNORI (JP)
YOSHIKAWA SEIJI (JP)
NISHIKAWA YOSHIHIRO (JP)
NAKAMURA TAIJU (JP)
HUKUYAMA TOHORU (JP)
International Classes:
C07D401/10; A61K31/4439; A61P25/28; A61P43/00; C07D211/76; C07D211/78; C07D233/61
Domestic Patent References:
| WO2005115990A1 | 2005-12-08 | |||
| WO2006046575A1 | 2006-05-04 | |||
| WO2004041776A2 | 2004-05-21 | |||
| WO2005087767A1 | 2005-09-22 |
Foreign References:
| JP2004536084A | 2004-12-02 | |||
| JPS521035A | 1977-01-06 | |||
| JPH09132578A | 1997-05-20 | |||
| JPH11513686A | 1999-11-24 |
Other References:
LUTZ FRIEDJAN TIETZE ET AL.: "Jikken Manual", vol. 2ND ED., 15 January 1995, NANKODO CO., LTD., pages: 196 - 199, XP003009081
Attorney, Agent or Firm:
ASAMURA, Kiyoshi et al. (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chome, Chiyoda-k, Tokyo 04, JP)
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