Title:
PROCESS FOR PRODUCTION OF INTERMEDIATES FOR THE SYNTHESIS OF CARBAPENEMS
Document Type and Number:
WIPO Patent Application WO/2006/028037
Kind Code:
A1
Abstract:
[PROBLEMS] There is a need for a process enabling industrially efficient production of 1-alkylcarboxylic acids, preferably 1β-alkylcarboxylic acids, which are useful as the raw material in the production of carbapenems or the like. [MEANS FOR SOLVING PROBLEMS] A process for the production of compounds (III) which comprises the step of oxidizing a compound (I) with ozone: (X) wherein R is a β-lactam ring group optionally substituted with a group which has no adverse effect on the oxidation with ozone; and R0 is hydrogen or lower alkyl optionally substituted with a group which has no adverse effect on the oxidation with ozone.
Inventors:
HAGIHARA MOTOYUKI (JP)
Application Number:
PCT/JP2005/016230
Publication Date:
March 16, 2006
Filing Date:
September 05, 2005
Export Citation:
Assignee:
SHIONOGI & CO (JP)
HAGIHARA MOTOYUKI (JP)
HAGIHARA MOTOYUKI (JP)
International Classes:
C07F7/18
Foreign References:
| JPS5726658A | 1982-02-12 | |||
| JPH05105660A | 1993-04-27 |
Other References:
MORI M. ET AL: "A simple and highly stereoselective route to a key intermediate carboxylic acid for the synthesis of 1beta-methylcarbapenems", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 11, 1993, pages 2389 - 2392, XP002993797
ITANI H. ET AL: "Two practical synthesis of a key intermediate of 1beta-methylcarbapenem antibiotics", SYNLETT., vol. 2, 1995, pages 213, XP002993798
ITANI H. ET AL: "Two practical synthesis of a key intermediate of 1beta-methylcarbapenem antibiotics", SYNLETT., vol. 2, 1995, pages 213, XP002993798
Attorney, Agent or Firm:
Yamauchi, Hideaki (Intellectual Property Department, 12-4, Sagisu
5-chome, Fukushima-k, Osaka-shi Osaka 02, JP)
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