Title:
PROCESS FOR PRODUCTION OF LIPOSOME THROUGH TWO-STAGE EMULSIFICATION USING MIXED ORGANIC SOLVENT AS OILY PHASE
Document Type and Number:
WIPO Patent Application WO/2011/062255
Kind Code:
A1
Abstract:
Disclosed is a process for producing a liposome, which comprises a two-stage emulsification step and a solvent removal step, and which is superior in the ratio of encapsulation of a drug or the like, the univesicular liposome formation efficiency and others compared with those of conventional processes. Specifically disclosed is a process for producing a liposome, which comprises: a primary emulsification step of emulsifying an inner aqueous phase (W1) and an oily phase (O) with a mixed lipid component (F1) for liposome applications to prepare a W1/O emulsion; a secondary emulsification step of emulsifying the W1/O emulsion and an outer aqueous phase (W2) with a mixed lipid component (F2) for liposome applications to prepare a W1/O/W2 emulsion; and a solvent removal step of removing an organic solvent contained in the oily phase (O) from the W1/O/W2 emulsion to form a liposome. The process is characterized in that the oily phase (O) in the W1/O/W2 emulsion to be subjected to the solvent removal step is a mixed organic solvent comprising at least two organic solvents.
Inventors:
WADA TAKESHI (JP)
ISODA TAKESHI (JP)
MOTOKUI YASUYUKI (JP)
ISODA TAKESHI (JP)
MOTOKUI YASUYUKI (JP)
Application Number:
PCT/JP2010/070657
Publication Date:
May 26, 2011
Filing Date:
November 19, 2010
Export Citation:
Assignee:
KONICA MINOLTA HOLDINGS INC (JP)
WADA TAKESHI (JP)
ISODA TAKESHI (JP)
MOTOKUI YASUYUKI (JP)
WADA TAKESHI (JP)
ISODA TAKESHI (JP)
MOTOKUI YASUYUKI (JP)
International Classes:
A61K9/127; A61K8/14; A61K9/52; B01J13/00
Domestic Patent References:
| WO2005053643A1 | 2005-06-16 | |||
| WO2008140081A1 | 2008-11-20 | |||
| WO2009107753A1 | 2009-09-03 |
Foreign References:
| JP2001515853A | 2001-09-25 | |||
| JP2006272196A | 2006-10-12 | |||
| JPH08505312A | 1996-06-11 |
Other References:
ISHII F. ET AL.: "Preparation conditions and evaluation of the stability of lipid vesicles (liposomes) using the microencapsulation technique", J DISPERS SCI TECHNOL, vol. 9, no. 1, 1988, pages 1 - 15
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
Patent business corporation SSINPAT (JP)
Patent business corporation SSINPAT (JP)
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