Title:
PROCESS FOR THE PRODUCTION OF MYCOPHENOLATE MOFETIL
Document Type and Number:
WIPO Patent Application WO2005023791
Kind Code:
A3
Abstract:
The present invention relates to a new and economically attractive process for the production of mycophenolate mofetil in a high degree of pharmaceutically acceptable purity, which comprises the reaction of a reactive derivative of mycophenolic acid with 4-(2-hydroxyethyl)morpholine under acidic reaction conditions and the subsequent extraction of the pure mycophenolate mofetil through salt formation and release of the free base. A further aspect of the invention relates to the purification of mycophenolate mofetil by removing its by products, in particular its dimeric by-products, by means of treatment with a primary or secondary amine.
Inventors:
GREIL JULIA (AT)
LUDESCHER JOHANNES (AT)
WOLF SIEGFRIED (AT)
LUDESCHER JOHANNES (AT)
WOLF SIEGFRIED (AT)
Application Number:
PCT/EP2004/010134
Publication Date:
November 17, 2005
Filing Date:
September 10, 2004
Export Citation:
Assignee:
SANDOZ AG (CH)
GREIL JULIA (AT)
LUDESCHER JOHANNES (AT)
WOLF SIEGFRIED (AT)
GREIL JULIA (AT)
LUDESCHER JOHANNES (AT)
WOLF SIEGFRIED (AT)
International Classes:
C07D307/88; (IPC1-7): C07D307/88
Domestic Patent References:
| WO2002100855A1 | 2002-12-19 | |||
| WO2000034503A2 | 2000-06-15 | |||
| WO1995007902A1 | 1995-03-23 |
Foreign References:
| US4748173A | 1988-05-31 | |||
| US5247083A | 1993-09-21 | |||
| US4686234A | 1987-08-11 | |||
| US4727069A | 1988-02-23 | |||
| EP0281713A1 | 1988-09-14 |
Download PDF: