Title:
PROCESS FOR PRODUCTION OF α-TRIFLUOROMETHYL-β-SUBSTITUTED- β-AMINO ACID
Document Type and Number:
WIPO Patent Application WO/2010/026918
Kind Code:
A1
Abstract:
An α-trifluoromethyl-β-substituted-β-amino acid can be produced by: reacting an α-trifluoromethyl-β-substituted-α,β- unsaturated ester with hydroxylamine to convert the α-trifluoromethyl-β-substituted-α,β-unsaturated ester into a dehydrogenated closed-ring form of an α-trifluoromethyl-β- substituted-β-amino acid; and hydrolyzing the dehydrogenated closed-ring form. This process can produce a novel α-trifluoromethyl-β-substituted-β-amino acid, which is a free amino acid having an unprotected functional group. In the process, a substituent at β-position is not limited to an aromatic ring group or a substituted aromatic ring group and the relative stereochemistry between α-position and β-position can be controlled.
Inventors:
ISHII AKIHIRO
YASUMOTO MANABU
YAMAZAKI TAKAKO
MOGI KAORI
MASUDA TAKASHI
YASUMOTO MANABU
YAMAZAKI TAKAKO
MOGI KAORI
MASUDA TAKASHI
Application Number:
PCT/JP2009/064971
Publication Date:
March 11, 2010
Filing Date:
August 27, 2009
Export Citation:
Assignee:
CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO
YASUMOTO MANABU
YAMAZAKI TAKAKO
MOGI KAORI
MASUDA TAKASHI
ISHII AKIHIRO
YASUMOTO MANABU
YAMAZAKI TAKAKO
MOGI KAORI
MASUDA TAKASHI
International Classes:
C07C227/32; C07C227/08; C07C229/20; C07D261/04; C07B61/00
Foreign References:
| JP2007502314A | 2007-02-08 | |||
| JP2002138070A | 2002-05-14 |
Other References:
JOURNAL OF ORGANIC CHEMISTRY, vol. 70, no. 14, 2005, pages 5721 - 5724, XP008144233
TETRAHEDRON (GREAT BRITAIN), vol. 62, 2006, pages 11760 - 11765
CHEMICAL COMMUNICATIONS (GREAT BRITAIN), 2006, pages 3628 - 3630
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
JOURNAL OF FLUORINE CHEMISTRY (HOLLAND), vol. 113, 2002, pages 177 - 183
TETRAHEDRON LETTERS (GREAT BRITAIN), vol. 42, 2001, pages 5929 - 5931
TETRAHEDRON (GREAT BRITAIN), vol. 62, 2006, pages 11760 - 11765
CHEMICAL COMMUNICATIONS (GREAT BRITAIN), 2006, pages 3628 - 3630
"Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC
JOURNAL OF FLUORINE CHEMISTRY (HOLLAND), vol. 113, 2002, pages 177 - 183
TETRAHEDRON LETTERS (GREAT BRITAIN), vol. 42, 2001, pages 5929 - 5931
Attorney, Agent or Firm:
HASHIMOTO, Takeshi et al. (JP)
Hashimoto 剛 (JP)
Hashimoto 剛 (JP)
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