A PROCESS FOR RESOLUTION OF 5-METHYLTETRAHYDROFOLIC ACID AND ITS SALIFICATION

Title:

A PROCESS FOR RESOLUTION OF 5-METHYLTETRAHYDROFOLIC ACID AND ITS SALIFICATION

Document Type and Number:

WIPO Patent Application WO/2008/031284

Kind Code:

A1

Abstract:

A process for preparation of calcium (6S)-5- methyltetrahydrofolate, including the following steps: resolution of racemic (6R,S)-5-methyltetrahydrofolic acid using α-phenethylamine to obtain (6S)-5- methyltetrahydrofolic acid and salification of (6S)-5- methyltetrahydrofolic acid with alkaline earth metal hydroxide especially calcium hydroxide to get calcium (6S)-5- methyltetrahydrofolate.

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Inventors:

CHEN XIN (CN)
ZHU GUANGXU (CN)
CHEN WEI (CN)

Application Number:

PCT/CN2006/002615

Publication Date:

March 20, 2008

Filing Date:

October 08, 2006

Export Citation:

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Assignee:

NAN JING RHINE PHARM TECH INC (CN)
CHEN XIN (CN)
ZHU GUANGXU (CN)
CHEN WEI (CN)

International Classes:

C07D475/04

Foreign References:

US5457202A

1995-10-10

Attorney, Agent or Firm:

NAN JING LAW OFFICE OF INTELLECTUAL PROPERTIES (Nanjing, Jiangsu 4, CN)

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