Title:
PROCESS FOR THE SYNTHESIS OF PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS
Document Type and Number:
WIPO Patent Application WO/2023/143605
Kind Code:
A1
Abstract:
The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors.The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I).The invention provides a process for preparing Intermediate B6*comprising reacting Intermediate B4*with Intermediate B5*in an atroposelective coupling reaction, using a chiral catalyst.
Inventors:
LI JIALIANG (CN)
BAENZIGER MARKUS (CH)
GALLOU FABRICE (CH)
GUO FENGFENG (CN)
HÄNGGI RUDOLF (CH)
HAN ENJIAN (CN)
JORDINE GUIDO (CH)
LIU WEIPENG (CN)
MIAO BUKEYAN (CN)
RONG SHAOFENG (CN)
SANTANDREA ERNESTO (CH)
SCHIRNER BERND (CH)
SHEN XIAODONG (CN)
WANG CAN (CN)
ZHANG HAO (CN)
BAENZIGER MARKUS (CH)
GALLOU FABRICE (CH)
GUO FENGFENG (CN)
HÄNGGI RUDOLF (CH)
HAN ENJIAN (CN)
JORDINE GUIDO (CH)
LIU WEIPENG (CN)
MIAO BUKEYAN (CN)
RONG SHAOFENG (CN)
SANTANDREA ERNESTO (CH)
SCHIRNER BERND (CH)
SHEN XIAODONG (CN)
WANG CAN (CN)
ZHANG HAO (CN)
Application Number:
PCT/CN2023/073833
Publication Date:
August 03, 2023
Filing Date:
January 30, 2023
Export Citation:
Assignee:
NOVARTIS AG (CH)
LI JIALIANG (CN)
LI JIALIANG (CN)
International Classes:
C07D403/14; A61P25/28; A61P35/00; C07D409/14; C07D417/14
Domestic Patent References:
| WO2021124222A1 | 2021-06-24 | |||
| WO2021174176A1 | 2021-09-02 | |||
| WO2015013318A1 | 2015-01-29 |
Other References:
HAYASHI DAISUKE, KATO NOBUO, KUZUYAMA TOMOHISA, SATO YASUO, OHKANDA JUNKO: "Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 49, no. 49, 28 February 2013 (2013-02-28), UK , pages 5535 - 5537, XP093082026, ISSN: 1359-7345, DOI: 10.1039/c3cc40758f
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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