Title:
PROCESSES FOR LARGE SCALE PRODUCTION OF TETRAPYRROLES
Document Type and Number:
WIPO Patent Application WO2002083686
Kind Code:
A3
Abstract:
The present invention relates to processes especially suitable for the large scale production of tetraphyrrolic compounds, such as meso-formyl porphyrins, mesoacrylate porphyrins, purpurins and benzochlorins. In particular, tin ethyl etiopurpurin (SnET2), sometimes called rostaporfin, and the intermediates necessary for its production without chromatography are disclosed. In addition, much of the chemistry disclosed is applicable to the large scale manufacturing of benzochlorins. Purpurins, benzochlorins and several of the intermediates in the synthesis may be useful as photosensitizers in photodynamic therapy, or as porphyrin building blocks in the synthesis of other porphyrinic materials.
Inventors:
ROBINSON BYRON C (US)
GARCIA BARBARA A (US)
GARCIA BARBARA A (US)
Application Number:
PCT/US2002/000520
Publication Date:
May 22, 2003
Filing Date:
January 23, 2002
Export Citation:
Assignee:
MIRAVANT PHARM INC (US)
ROBINSON BYRON C (US)
GARCIA BARBARA A (US)
ROBINSON BYRON C (US)
GARCIA BARBARA A (US)
International Classes:
A61K41/00; C07D487/22; (IPC1-7): C07D487/22
Domestic Patent References:
| WO1994000118A1 | 1994-01-06 |
Foreign References:
| US5656756A | 1997-08-12 | |||
| US5051415A | 1991-09-24 |
Download PDF: