PROCESSES OF MAKING ONAPRISTONE AND INTERMEDIATES THEREOF

Title:

PROCESSES OF MAKING ONAPRISTONE AND INTERMEDIATES THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/000135

Kind Code:

A1

Abstract:

Provided are new process and intermediates for preparing onapristone.

Inventors:

WUTS PETER (US)
RENCHER WILLIAM F (US)
ZHANG TONY (CN)
ZHONG BOYU (CN)
YANG ANJIANG (CN)
LV FEI (CN)
ZHAO QIHUA (CN)
FENG JIAOYANG (CN)
WANG JIFA (CN)

Application Number:

PCT/CN2021/107099

Publication Date:

January 26, 2023

Filing Date:

July 19, 2021

Export Citation:

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Assignee:

CONTEXT BIOPHARMA INC (US)
TYLIGAND BIOSCIENCE SHANGHAI LTD (CN)

International Classes:

C07J9/00; C07C401/00; C07D319/08

Domestic Patent References:

WO1995029931A1	1995-11-09
WO2017053793A1	2017-03-30

Foreign References:

JPS6041695A

1985-03-05

Other References:

CHEN, GUOHUA; TU, SHUZHI; LIAO, QINGJIANG: "Synthesis of progesterone receptor antagonist ZK 98299", JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, NAJING, CN, vol. 23, no. 4, 1 January 1992 (1992-01-01), CN , pages 209 - 12, XP009513831, ISSN: 1000-5048
DEBONO AARON, THOMAS DAVID R., LUNDBERG LINDSAY, PINKHAM CHELSEA, CAO YING, GRAHAM J. DINNY, CLARKE CHRISTINE L., WAGSTAFF KYLIE M: "Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity", SCIENTIFIC REPORTS, vol. 9, no. 1, XP093025998, DOI: 10.1038/s41598-019-38671-y

Attorney, Agent or Firm:

YONG HUI INTELLECTUAL PROPERTY (CN)

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