Title:
PROCESSES FOR THE PREPARATION OF (3R,4S)-4-((4-BENZYLOXY)PHENYL)-1-(4-FLUOROPHENYL)-3-((S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-2-AZETIDINONE, AN INTERMEDIATE FOR THE SYNTHESIS OF EZETIMIBE
Document Type and Number:
WIPO Patent Application WO2007030721
Kind Code:
A9
Abstract:
The invention encompasses (3R,4S)-4-((4-benzyloxy)phenyl)-l-(4-fluorophenyl)-3- (3-(4-fluorophenyl)-3-oxopropyl)-2-azetidinone (Compound 2a). The invention further encompasses processes tor preparing Compound 2a from Compound 1. The invention also encompasses processes for preparing a compound having Formula (A) from a compound having the formula (B); wherein R is selected from the group consisting of: H or a hydroxyl protecting group. The invention also encompasses processes for preparing Compound 2a, preferably to form Compound 2a-Form 01. Also included are processes for preparing ezetimibe from Compound 2a-Form 01 or Compound 2a prepared according to the invention, compositions containing such ezetimibe, and methods for reducing cholesterol using such compositions.
Inventors:
KANSAL VINOD KUMAR (IN)
AHMAD SUHAIL (IN)
TYAGI BHUPENDRA (IN)
GUPTA NITIN (IN)
PERLMAN NURIT (IL)
AHMAD SUHAIL (IN)
TYAGI BHUPENDRA (IN)
GUPTA NITIN (IN)
PERLMAN NURIT (IL)
Application Number:
PCT/US2006/035060
Publication Date:
April 24, 2008
Filing Date:
September 08, 2006
Export Citation:
Assignee:
TEVA PHARMA (US)
TEVA PHARMA (US)
KANSAL VINOD KUMAR (IN)
AHMAD SUHAIL (IN)
TYAGI BHUPENDRA (IN)
GUPTA NITIN (IN)
PERLMAN NURIT (IL)
TEVA PHARMA (US)
KANSAL VINOD KUMAR (IN)
AHMAD SUHAIL (IN)
TYAGI BHUPENDRA (IN)
GUPTA NITIN (IN)
PERLMAN NURIT (IL)
International Classes:
C07D205/08; A61K31/397; A61P3/04
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