Title:
PROCESSES FOR THE PREPARATION OF GLUTAMIC ACID COMPOUNDS AND INTERMEDIATES THEREOF AND NOVEL INTERMEDIATES USED IN THE PROCESSES
Document Type and Number:
WIPO Patent Application WO/2003/059865
Kind Code:
A1
Abstract:
A process for preparing industrially and efficiently glutamic acid compounds (such as monatin) useful as sweeteners or intermediates for the production of drugs or the like&semi a process for preparation of intermediates used therein&semi novel intermediates included among them&semi a process for preparation of optically active monatin&semi a process for preparation of intermediates used therein&semi and novel intermediates included among them. Specifically, a process for the preparation of glutamic acid compounds (or salts thereof) including monatin, which comprises preparing a ketoglutaric acid compound serving as a precursor of the objective glutamic acid compound by condensing a specific pyruvic acid compound with oxalacetic acid or pyruvic acid through cross−aldol reaction and, if necessary, subjecting the obtained condensate to decarboxylation, and replacing the carbonyl group of the ketoglutaric acid compound by an amino group.
Inventors:
KAWAHARA SHIGERU (JP)
AMINO YUSUKE (JP)
MORI KENICHI (JP)
FUNAKOSHI NAO (JP)
TAKEMOTO TADASHI (JP)
AMINO YUSUKE (JP)
MORI KENICHI (JP)
FUNAKOSHI NAO (JP)
TAKEMOTO TADASHI (JP)
Application Number:
PCT/JP2002/012473
Publication Date:
July 24, 2003
Filing Date:
November 29, 2002
Export Citation:
Assignee:
AJINOMOTO KK (JP)
KAWAHARA SHIGERU (JP)
AMINO YUSUKE (JP)
MORI KENICHI (JP)
FUNAKOSHI NAO (JP)
TAKEMOTO TADASHI (JP)
KAWAHARA SHIGERU (JP)
AMINO YUSUKE (JP)
MORI KENICHI (JP)
FUNAKOSHI NAO (JP)
TAKEMOTO TADASHI (JP)
International Classes:
A23L2/60; A23L27/10; A23L27/20; A23L27/30; C07C51/38; C07C229/24; C07C229/36; C07D209/08; C07D209/20; (IPC1-7): C07C229/36; C07C51/353; C07C51/38; C07C59/285; C07C59/347; C07C59/48; C07C227/08; C07C229/24; C07C251/36; C07D209/08
Foreign References:
| US3751458A | 1973-08-07 | |||
| EP0438314A1 | 1991-07-24 | |||
| US4975298A | 1990-12-04 |
Other References:
JUHL KARSTEN ET AL.: "Catalytic asymmetric homoaldol reaction of pyruvate-a chiral Lewis acid catalyst that mimics aldolase enzymes", CHEMICAL COMMUNICATIONS, no. 22, 2000, pages 2211 - 2212, XP002966856
BULDAIN GRACIELA ET AL.: "Carbon-13 nuclear magnetic resonance spectra of the hydrate, keto and enol forms of oxalacetic acid", MAGNETIC RESONANCE IN CHEMISTRY, vol. 23, no. 6, 1985, pages 478 - 481, XP002966857
"Amino-san Kogyo - Gosei to Riyo", KODANSHA LTD., pages 8 - 9, XP002966858
BULDAIN GRACIELA ET AL.: "Carbon-13 nuclear magnetic resonance spectra of the hydrate, keto and enol forms of oxalacetic acid", MAGNETIC RESONANCE IN CHEMISTRY, vol. 23, no. 6, 1985, pages 478 - 481, XP002966857
"Amino-san Kogyo - Gosei to Riyo", KODANSHA LTD., pages 8 - 9, XP002966858
Attorney, Agent or Firm:
Ishida, Yasumasa (Bohsei Bldg. 7th Floor, 20-12, Shin-Yokohama
3-chome, Kohoku-k, Yokohama-shi Kanagawa, JP)
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