Title:
PROCESSES FOR PREPARATION OF TETRAHYDRONAPHTHALENE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2002/042243
Kind Code:
A1
Abstract:
Processes for preparing optically active intermediates for the synthesis of tetrahydronaphthalene derivatives useful as PGI¿2? agonist can be provided by providing a method for optical resolution of a tetrahydronaphthalene derivative of the following general formula with a reagent for optical resolution and a method for inversion of such a derivative at its asymmetric center. In the formula, R?1¿ is a hydroxyl-protecting group; R?2¿ is hydrogen or halogeno; R?3¿ is hydrogen, hydroxyl, or protected hydroxyl; and R?4¿ is hydrogen, hydroxyl, protected hydroxyl, lower alkyl, or halogeno.
Inventors:
ICHIHARA MASAHARU (JP)
HASHIMOTO NORIO (JP)
OHIGASHI ATSUSHI (JP)
KANDA ATSUSHI (JP)
KAGARA KOOJI (JP)
MORIKI SHIGERU (JP)
BABA YUKIHISA (JP)
HASHIMOTO NORIO (JP)
OHIGASHI ATSUSHI (JP)
KANDA ATSUSHI (JP)
KAGARA KOOJI (JP)
MORIKI SHIGERU (JP)
BABA YUKIHISA (JP)
Application Number:
PCT/JP2001/009861
Publication Date:
May 30, 2002
Filing Date:
November 12, 2001
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO (JP)
ICHIHARA MASAHARU (JP)
HASHIMOTO NORIO (JP)
OHIGASHI ATSUSHI (JP)
KANDA ATSUSHI (JP)
KAGARA KOOJI (JP)
MORIKI SHIGERU (JP)
BABA YUKIHISA (JP)
ICHIHARA MASAHARU (JP)
HASHIMOTO NORIO (JP)
OHIGASHI ATSUSHI (JP)
KANDA ATSUSHI (JP)
KAGARA KOOJI (JP)
MORIKI SHIGERU (JP)
BABA YUKIHISA (JP)
International Classes:
C07B57/00; (IPC1-7): C07B57/00; C07B53/00; C07B55/00; C07C37/01; C07C39/38; C07C41/26; C07C41/32; C07C43/23
Domestic Patent References:
| WO2000078350A1 | 2000-12-28 | |||
| WO1995024393A1 | 1995-09-14 |
Foreign References:
| JPH09187292A | 1997-07-22 | |||
| JPH07196565A | 1995-08-01 | |||
| JPH04211074A | 1992-08-03 |
Other References:
RUANO JOSE L. GARCIA ET AL.: "A new stereo-controlled entry into the anthracyclinone families. Part 1. Synthesis of bicyclic precursors of 4-demethoxy-7-deoxy-derivatives", TETRAHEDRON ASYMMETRY, vol. 10, no. 15, 1999, pages 2935 - 2944, XP004179149
KIM HEE-DOO ET AL.: "A novel synthetic route to 11-deoxyanthracycline AB synthons", ARCH. PHARMACOL. RES., vol. 17, no. 4, 1994, pages 249 - 255, XP002908284
IZAWA TOSHIO ET AL.: "A novel enantiocontrolled synthesis of (+)-9-deacetyl-9-(hydroxymethyl)-4-demethoxydaunomycinone", CHEM. LETT., no. 8, 1987, pages 1655 - 1656, XP002908285
COREY E.J. ET AL.: "Short enantioselective synthesis of (-)-ovalicin, a potent inhibitor of angiogenesis, using substrate-enhanced catalytic asymmetric dihydroxylation", J. AM. CHEM. SOC., vol. 116, no. 26, 1994, pages 12109 - 12110, XP002908286
KIM HEE-DOO ET AL.: "A novel synthetic route to 11-deoxyanthracycline AB synthons", ARCH. PHARMACOL. RES., vol. 17, no. 4, 1994, pages 249 - 255, XP002908284
IZAWA TOSHIO ET AL.: "A novel enantiocontrolled synthesis of (+)-9-deacetyl-9-(hydroxymethyl)-4-demethoxydaunomycinone", CHEM. LETT., no. 8, 1987, pages 1655 - 1656, XP002908285
COREY E.J. ET AL.: "Short enantioselective synthesis of (-)-ovalicin, a potent inhibitor of angiogenesis, using substrate-enhanced catalytic asymmetric dihydroxylation", J. AM. CHEM. SOC., vol. 116, no. 26, 1994, pages 12109 - 12110, XP002908286
Attorney, Agent or Firm:
Tabushi, Eiji c/o Fujisawa Pharmaceutical Co. (Ltd. Osaka Factory 1-6 Kashima 2-chom, Yodogawa-ku Osaka-shi Osaka, JP)
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