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Title:
PROCESSES FOR PRODUCING OPTICALLY ACTIVE 2-THIOMETHYL-3-PHENYLPROPIONIC ACID DERIVATIVE AND FOR PRODUCING INTERMEDIATE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2004/060885
Kind Code:
A1
Abstract:
A process for easily producing from an inexpensive material an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines. An optically active 2-hydroxymethyl-3-phenylpropionic ester derivative which is relatively easily obtained by an asymmetric reduction reaction promoted by an enzyme is cyclized to an optically active β-lactone derivative. The resultant derivative is reacted with a sulfur compound. Thus, the optically active 2-thiomethyl-3-phenylpropionic acid derivative is produced in a satisfactory yield.

Inventors:
OHISHI TAKAHIRO (JP)
MORI KOHEI (JP)
KINOSHITA KOICHI (JP)
MAEHARA KATSUJI (JP)
KAWASAKI HIROAKI (JP)
NAGASHIMA NOBUO (JP)
FUSE YOSHIHIDE (JP)
Application Number:
PCT/JP2003/015821
Publication Date:
July 22, 2004
Filing Date:
December 10, 2003
Export Citation:
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Assignee:
KANEKA CORP (JP)
OHISHI TAKAHIRO (JP)
MORI KOHEI (JP)
KINOSHITA KOICHI (JP)
MAEHARA KATSUJI (JP)
KAWASAKI HIROAKI (JP)
NAGASHIMA NOBUO (JP)
FUSE YOSHIHIDE (JP)
International Classes:
C07C319/14; C07C323/56; (IPC1-7): C07D407/06; C07D317/60; C07D305/12
Domestic Patent References:
WO2003059869A12003-07-24
WO1998005634A11998-02-12
WO1997037665A11997-10-16
WO1997029086A11997-08-14
WO1995005374A11995-02-23
Foreign References:
JP2003000295A2003-01-07
FR2772027A11999-06-11
EP0906901A21999-04-07
EP0309766A21989-04-05
Other References:
KIM ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 8, 2002, pages 2553 - 2560, XP002977635
Attorney, Agent or Firm:
KANEKA CORPORATION (Kita-ku Osaka-shi, Osaka, JP)
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