Title:
PRODRUG COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/032569
Kind Code:
A1
Abstract:
The present invention provides a prodrug compound, a preparation method therefor and a use thereof. Specifically, the present invention provides a compound represented by formula (I), a preparation method therefor, and a use thereof as a prodrug in the preparation of an external preparation.
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Inventors:
LI AO (CN)
JIADAFU PRABHAKAR KONDAJI (CN)
CHEN YILE (CN)
CAO GUOQING (CN)
JIADAFU PRABHAKAR KONDAJI (CN)
CHEN YILE (CN)
CAO GUOQING (CN)
Application Number:
PCT/CN2023/111594
Publication Date:
February 15, 2024
Filing Date:
August 07, 2023
Export Citation:
Assignee:
MINGHUI PHARMACEUTICAL HANGZHOU LTD (CN)
MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN)
MINGHUI PHARMACEUTICAL SHANGHAI LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/506; A61K31/519; A61P3/00; A61P19/00; A61P29/00; A61P37/02; C07C259/10; C07D213/81; C07D213/82; C07D235/06; C07D487/04; C07D487/08; C07D513/08
Foreign References:
| CN114907353A | 2022-08-16 | |||
| IN2015MU02957A | ||||
| CN1329671A | 2002-01-02 | |||
| US20070275963A1 | 2007-11-29 | |||
| CN109867676A | 2019-06-11 | |||
| CN108290918A | 2018-07-17 | |||
| CN113372351A | 2021-09-10 |
Other References:
DATABASE REGISTRY 30 March 1985 (1985-03-30), ANONYMOUS : "1-Piperazineacetamide, 4-[2-(acetyloxy)-3-(2- methoxyphenoxy)pr opyl]-N-(2,6- dimethylphenyl)- (CA INDEX NAME)", XP093138102, retrieved from STN Database accession no. 95635-90-8
DATABASE REGISTRY 13 September 2019 (2019-09-13), ANONYMOUS : "Benzoic acid, 4-methoxy -, [(2R,5S)-5-(4-amin o-5-fluoro-2-oxo-1(2 H)- pyrimidinyl)-1,3-oxa thiolan-2-yl]methyl ester, rel- (CA INDEX NAME)", XP093138104, retrieved from STN Database accession no. 2375192-66-6
DATABASE REGISTRY 2 March 2015 (2015-03-02), ANONYMOUS : "Butanedioic acid, 1-[2-[4 -[6-[[5-[[(2-chloro-6- methylphenyl)amin o]carbonyl]-2-thiazo lyl]amino]-2-methyl4-pyrimidinyl]-1- piperazinyl]ethyl] es ter (CA INDEX NAME)", XP093138105, retrieved from STN Database accession no. 1654008-88-4
张万年主编 (ZHANG, WANNIAN, EDITOR-IN-CHIEF): "前药设计原理 (Non-official translation: Principles of Prodrug Design)", 现代药物设计学 (NON-OFFICIAL TRANSLATION: MODERN DRUG DESIGN), 北京:中国医药科技出版社 (BEIJING: CHINA MEDICAL SCIENCE PRESS), ISBN 7-5067-3293-9/G•0461, FIRST EDITION, MAY 2006, 31 May 2006 (2006-05-31), pages 86 - 87
DATABASE REGISTRY 13 September 2019 (2019-09-13), ANONYMOUS : "Benzoic acid, 4-methoxy -, [(2R,5S)-5-(4-amin o-5-fluoro-2-oxo-1(2 H)- pyrimidinyl)-1,3-oxa thiolan-2-yl]methyl ester, rel- (CA INDEX NAME)", XP093138104, retrieved from STN Database accession no. 2375192-66-6
DATABASE REGISTRY 2 March 2015 (2015-03-02), ANONYMOUS : "Butanedioic acid, 1-[2-[4 -[6-[[5-[[(2-chloro-6- methylphenyl)amin o]carbonyl]-2-thiazo lyl]amino]-2-methyl4-pyrimidinyl]-1- piperazinyl]ethyl] es ter (CA INDEX NAME)", XP093138105, retrieved from STN Database accession no. 1654008-88-4
张万年主编 (ZHANG, WANNIAN, EDITOR-IN-CHIEF): "前药设计原理 (Non-official translation: Principles of Prodrug Design)", 现代药物设计学 (NON-OFFICIAL TRANSLATION: MODERN DRUG DESIGN), 北京:中国医药科技出版社 (BEIJING: CHINA MEDICAL SCIENCE PRESS), ISBN 7-5067-3293-9/G•0461, FIRST EDITION, MAY 2006, 31 May 2006 (2006-05-31), pages 86 - 87
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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