Title:
PRODRUGS ACTIVATED BY CASPASE
Document Type and Number:
WIPO Patent Application WO/2016/080626
Kind Code:
A2
Abstract:
Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce apoptosis, amplify apoptosis, and treat cancer.
Inventors:
KIM SANG YOON (KR)
BYUN YOUNG RO (KR)
CHUNG SEUNG WOO (KR)
BYUN YOUNG RO (KR)
CHUNG SEUNG WOO (KR)
Application Number:
PCT/KR2015/007165
Publication Date:
May 26, 2016
Filing Date:
July 10, 2015
Export Citation:
Assignee:
PHAROSGEN (KR)
International Classes:
C07D309/10; A61K31/4015; A61K31/7042; A61K38/08; A61K47/48; A61P35/00
Domestic Patent References:
| WO2001062300A2 | 2001-08-30 | |||
| WO2014120837A2 | 2014-08-07 | |||
| WO2008009878A1 | 2008-01-24 |
Foreign References:
| US7445764B1 | 2008-11-04 | |||
| US20100111866A1 | 2010-05-06 | |||
| US20130338422A1 | 2013-12-19 |
Other References:
MEYER-LOSIC, F. ET AL., J. MED. CHEM., vol. 49, 2006, pages 6908 - 16
See also references of EP 3049399A4
See also references of EP 3049399A4
Attorney, Agent or Firm:
DARAE IP FIRM (131 Teheran-ro,Gangnam-gu, Seoul 135-080, KR)
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