Title:
PRODRUGS OF MITOTIC KINESIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO2004111193
Kind Code:
A3
Abstract:
The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Inventors:
FRALEY MARK E (US)
GARBACCIO ROBERT M (US)
HARTMAN GEORGE D (US)
HOFFMAN WILLIAM F (US)
GARBACCIO ROBERT M (US)
HARTMAN GEORGE D (US)
HOFFMAN WILLIAM F (US)
Application Number:
PCT/US2004/018065
Publication Date:
March 24, 2005
Filing Date:
June 08, 2004
Export Citation:
Assignee:
MERCK & CO INC (US)
FRALEY MARK E (US)
GARBACCIO ROBERT M (US)
HARTMAN GEORGE D (US)
HOFFMAN WILLIAM F (US)
FRALEY MARK E (US)
GARBACCIO ROBERT M (US)
HARTMAN GEORGE D (US)
HOFFMAN WILLIAM F (US)
International Classes:
C07D207/20; C07D209/48; C07D401/12; C07F9/572; C07F9/6558; C12N; (IPC1-7): C07D207/20
Other References:
DATABASE CAS ONLINE [online] 15 January 2004 (2004-01-15), XP002987525, accession no. STN Database accession no. 2004:41221
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