Title:
PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
Document Type and Number:
WIPO Patent Application WO2003028729
Kind Code:
A3
Abstract:
The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.
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Inventors:
SOUTH MICHAEL S (US)
WEBBER RONALD K (US)
HUANG HORNG-CHIH (US)
TOTH MIHALY V (US)
MOORMANN ALAN E (US)
SNYDER JEFFREY S (US)
SCHOLTEN JEFFREY A (US)
GARLAND DANNY J (US)
RUEPPEL MELVIN L (US)
NEUMANN WILLIAM L (US)
LONG SCOTT (US)
WEI HUANG (US)
TRUJILLO JOHN (US)
PARLOW JOHN J (US)
JONES DARIN E (US)
CASE BRENDA (US)
HAYES MICHAEL J (US)
ZENG QINGPING (US)
WEBBER RONALD K (US)
HUANG HORNG-CHIH (US)
TOTH MIHALY V (US)
MOORMANN ALAN E (US)
SNYDER JEFFREY S (US)
SCHOLTEN JEFFREY A (US)
GARLAND DANNY J (US)
RUEPPEL MELVIN L (US)
NEUMANN WILLIAM L (US)
LONG SCOTT (US)
WEI HUANG (US)
TRUJILLO JOHN (US)
PARLOW JOHN J (US)
JONES DARIN E (US)
CASE BRENDA (US)
HAYES MICHAEL J (US)
ZENG QINGPING (US)
Application Number:
PCT/US2002/031468
Publication Date:
September 16, 2004
Filing Date:
October 03, 2002
Export Citation:
Assignee:
PHARMACIA CORP (US)
SOUTH MICHAEL S (US)
WEBBER RONALD K (US)
HUANG HORNG-CHIH (US)
TOTH MIHALY V (US)
MOORMANN ALAN E (US)
SNYDER JEFFREY S (US)
SCHOLTEN JEFFREY A (US)
GARLAND DANNY J (US)
RUEPPEL MELVIN L (US)
NEUMANN WILLIAM L (US)
LONG SCOTT (US)
WEI HUANG (US)
TRUJILLO JOHN (US)
PARLOW JOHN J (US)
JONES DARIN E (US)
CASE BRENDA (US)
HAYES MICHAEL J (US)
ZENG QINGPING (US)
SOUTH MICHAEL S (US)
WEBBER RONALD K (US)
HUANG HORNG-CHIH (US)
TOTH MIHALY V (US)
MOORMANN ALAN E (US)
SNYDER JEFFREY S (US)
SCHOLTEN JEFFREY A (US)
GARLAND DANNY J (US)
RUEPPEL MELVIN L (US)
NEUMANN WILLIAM L (US)
LONG SCOTT (US)
WEI HUANG (US)
TRUJILLO JOHN (US)
PARLOW JOHN J (US)
JONES DARIN E (US)
CASE BRENDA (US)
HAYES MICHAEL J (US)
ZENG QINGPING (US)
International Classes:
A61K31/4375; A61K31/4965; A61K31/497; A61K31/4985; A61K31/536; A61K31/5377; A61K45/00; A61P7/02; A61P9/00; A61P11/00; A61P43/00; C07C257/18; C07D207/32; C07D211/56; C07D211/98; C07D213/74; C07D231/38; C07D231/48; C07D237/04; C07D239/10; C07D239/22; C07D241/04; C07D241/20; C07D249/14; C07D253/06; C07D253/075; C07D263/48; C07D265/02; C07D277/42; C07D307/22; C07D333/36; C07D401/12; C07D403/10; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D471/04; (IPC1-7): A61K31/4965; A61K31/497; C07D241/20; C07D401/12; C07D407/12; C07D413/12; C07D471/04
Domestic Patent References:
| WO2000069834A1 | 2000-11-23 | |||
| WO1999059591A1 | 1999-11-25 | |||
| WO1998017274A1 | 1998-04-30 | |||
| WO2001087854A1 | 2001-11-22 | |||
| WO2002042272A2 | 2002-05-30 |
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