Title:
PRODUCT AND METHOD FOR TREATMENT OF CONDITIONS ASSOCIATED WITH RECEPTOR-DESENSITIZATION
Document Type and Number:
WIPO Patent Application WO2000050081
Kind Code:
A9
Abstract:
Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell receptor (pro-BCR), Ig Fc receptors (FcR), and NK receptors, can be physically uncoupled from their associated transducers. The invention describes regulatory compounds and methods for mimicking such dissociation/destabilization for the purposes of receptor desensitization and for treatment of conditions in which receptor desensitization or alternatively, enhanced or prolonged receptor sensitization, is desirable. Compounds and methods for enhancing or prolonging receptor sensitization are also disclosed, as are methods for identifying regulatory compounds suitable for use in the present methods.
Inventors:
VILEN BARBARA J
CAMBIER JOHN C
CAMBIER JOHN C
Application Number:
PCT/US2000/004791
Publication Date:
July 04, 2002
Filing Date:
February 25, 2000
Export Citation:
Assignee:
NAT JEWISH MED & RES CENTER (US)
International Classes:
A61P37/02; C07K16/28; G01N33/50; G01N33/566; (IPC1-7): A61K39/395; G01N33/53
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