Title:
PRODUCTION OF THE DIGESTION-RESISTANT PEPTIDE WITH ANTIHYPERTENSIVE HEALTH ACTIVITY TO REPLACE IT WITH SYNTHETIC BLOOD PRESSURE DRUGS.
Document Type and Number:
WIPO Patent Application WO/2023/166356
Kind Code:
A1
Abstract:
The protein concentrate of orange seed was hydrolyzed using the digestive enzyme alcalase at a temperature of 50 C° and a pH of 8 for 3.5 hours in sugar-coated incubators, and after a specified period of time, the enzyme used at a temperature of 90 Cº was deactivated for 5 minutes, and then the supernatant resulting from centrifugation (12000 rpm for 15 minutes) were kept at -20 Cº after freeze drying by dryer and finally after separating and purifying the peptides using chromatography method, the resulting peptides were examined in terms of their antihypertensive health properties. In order to influence the body's digestive conditions on the health properties, gastric and intestinal digestion simulation conditions were used in the extracorporeal environment. The health-giving peptides also include: Reducing the activity of ACE enzyme and then preventing high blood pressure as well as cardiovascular diseases. Beneficial peptides with antihypertensive potential.
Inventors:
MAZLOOMIKIYAPEY SEYADEHNARGES (IR)
Application Number:
PCT/IB2023/050247
Publication Date:
September 07, 2023
Filing Date:
January 11, 2023
Export Citation:
Assignee:
MAZLOOMIKIYAPEY SEYADEHNARGES (IR)
International Classes:
A23L33/18; A61P9/12
Other References:
MAZLOOMI SEYADEH NARGES, MORA LETICIA, ARISTOY M-CONCEPCIÓN, MAHOONAK ALIREZA SADEGHI, GHORBANI MOHAMMAD, HOUSHMAND GHOLAMREZA, TO: "Impact of Simulated Gastrointestinal Digestion on the Biological Activity of an Alcalase Hydrolysate of Orange Seed (Siavaraze, Citrus sinensis) by-Products", FOODS, vol. 9, no. 9, pages 1217, XP093091026, DOI: 10.3390/foods9091217
FATHOLLAHY ISA, FARMANI JAMSHID, KASAAI MOHAMMAD REZA, HAMISHEHKAR HAMED: "Characteristics and functional properties of Persian lime (Citrus latifolia) seed protein isolate and enzymatic hydrolysates", LWT- FOOD SCIENCE AND TECHNOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 140, 1 April 2021 (2021-04-01), United Kingdom , pages 110765, XP093091028, ISSN: 0023-6438, DOI: 10.1016/j.lwt.2020.110765
R. CHANDRASEKAR, B. SIVAGAMI: "EDIBLE SEEDS MEDICINAL VALUE, THERAPEUTIC APPLICATIONS AND FUNCTIONAL PROPERTIES-A REVIEW", INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, pages 11 - 18, XP093091029, ISSN: 2656-0097, DOI: 10.22159/ijpps.2021v13i7.41436
FATHOLLAHY ISA, FARMANI JAMSHID, KASAAI MOHAMMAD REZA, HAMISHEHKAR HAMED: "Characteristics and functional properties of Persian lime (Citrus latifolia) seed protein isolate and enzymatic hydrolysates", LWT- FOOD SCIENCE AND TECHNOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 140, 1 April 2021 (2021-04-01), United Kingdom , pages 110765, XP093091028, ISSN: 0023-6438, DOI: 10.1016/j.lwt.2020.110765
R. CHANDRASEKAR, B. SIVAGAMI: "EDIBLE SEEDS MEDICINAL VALUE, THERAPEUTIC APPLICATIONS AND FUNCTIONAL PROPERTIES-A REVIEW", INTERNATIONAL JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, pages 11 - 18, XP093091029, ISSN: 2656-0097, DOI: 10.22159/ijpps.2021v13i7.41436
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