Title:
PRODUCTION METHOD FOR DISEASE MODEL NON-HUMAN ANIMAL, DISEASE MODEL NON-HUMAN ANIMAL, DRUG SCREENING METHOD USING DISEASE MODEL NON-HUMAN ANIMAL, AND DISEASE RISK DETERMINATION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/159787
Kind Code:
A1
Abstract:
[Problem] The purpose of the present invention is to provide: a method for making an animal that has been stressed, and, in particular, chronically stressed, contract or present a specific disease or symptoms; and a tool that, by elucidating the process by which the stress leads to contracting or presenting the disease or symptoms, is useful for research and development related to the prevention or treatment of the disease or symptoms. [Solution] The present invention relates to: a production method for a disease model non-human animal that has inflamed intracerebral blood vessels; the disease model non-human animal; a drug screening method that uses the disease model non-human animal; a disease risk determination method that uses the presence of inflamed blood vessels as an indicator; and a pharmaceutical for preventing and/or treating progressive multiple sclerosis or the like. The present invention makes it possible to develop a pharmaceutical for the abovementioned disease or the like and to perform research to elucidate mechanisms of pathogenesis. The present invention also makes it possible to determine the risk of contracting or presenting progressive multiple sclerosis or the like and to prevent and/or treat progressive multiple sclerosis or the like.
Inventors:
MURAKAMI MASAAKI (JP)
KAMIMURA DAISUKE (JP)
ARIMA YASUNOBU (JP)
KAMIMURA DAISUKE (JP)
ARIMA YASUNOBU (JP)
Application Number:
PCT/JP2018/007901
Publication Date:
September 07, 2018
Filing Date:
March 01, 2018
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A01K67/027; A61K45/00; A61P1/04; A61P9/04; A61P25/00; G01N33/15; G01N33/50
Foreign References:
| JP2009526786A | 2009-07-23 | |||
| JP2013503192A | 2013-01-31 | |||
| JP2011502149A | 2011-01-20 | |||
| JP2012107021A | 2012-06-07 |
Other References:
ARIMA, T. ET AL.: "A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model", ELIFE, vol. 4, 2015, pages 1 - 23, XP055543487, ISSN: 2050-084X, Retrieved from the Internet
BENAMAR, K. ET AL.: "Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 592, no. 1-3, 11 July 2008 (2008-07-11), pages 93 - 95, XP024098628, ISSN: 0014-2999, Retrieved from the Internet
BENAMAR, K. ET AL.: "Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 592, no. 1-3, 11 July 2008 (2008-07-11), pages 93 - 95, XP024098628, ISSN: 0014-2999, Retrieved from the Internet
Attorney, Agent or Firm:
IP-ASSIST PATENT OFFICE (JP)
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