Title:
PRODUCTION METHOD OF INTERMEDIATE FOR RADIOPHARMACEUTICAL COMPOSITION, AND PURIFICATION KIT FOR INTERMEDIATE FOR RADIOPHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2024/058201
Kind Code:
A1
Abstract:
The purpose of the present invention is to produce an intermediate for a radioactive antibody drug having a higher purity. A production method of the present invention includes an adsorption step for adsorbing a composition containing an intermediate on a stationary phase for hydrophobic chromatography, and a purification step for eluting the intermediate from the stationary phase. The intermediate is a complex of an anti-epidermal growth factor receptor antibody (anti-EGFR antibody) and 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA).
Inventors:
YOSHII YUKIE (JP)
MATSUMOTO HIROKI (JP)
MATSUMOTO HIROKI (JP)
Application Number:
PCT/JP2023/033315
Publication Date:
March 21, 2024
Filing Date:
September 13, 2023
Export Citation:
Assignee:
NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECH (JP)
International Classes:
A61K51/04; A61K51/10; A61P35/00
Foreign References:
| JP2017214308A | 2017-12-07 | |||
| JP2017507132A | 2017-03-16 | |||
| JP2011514895A | 2011-05-12 | |||
| JP2005524700A | 2005-08-18 | |||
| JP2018502139A | 2018-01-25 | |||
| JP2009540015A | 2009-11-19 | |||
| JP2009530380A | 2009-08-27 |
Other References:
YOSHII YUKIE, YOSHIMOTO MITSUYOSHI, MATSUMOTO HIROKI, TASHIMA HIDEAKI, IWAO YUMA, TAKUWA HIROYUKI, YOSHIDA EIJI, WAKIZAKA HIDEKATS: "Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with 64 Culabeled cetuximab to treat early-and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts", ONCOTARGET, IMPACT JOURNALS LLC, UNITED STATES, vol. 9, no. 48, 22 June 2018 (2018-06-22), United States , pages 28935 - 28950, XP093148547, ISSN: 1949-2553
SONG IN HO, LEE TAE SUP, PARK YONG SERK, LEE JIN SOOK, LEE BYUNG CHUL, MOON BYUNG SEOK, AN GWANG IL, LEE HAE WON, KIM KWANG IL, LE: "Immuno-PET Imaging and Radioimmunotherapy of 64 Cu-/ 177 Lu-Labeled Anti-EGFR Antibody in Esophageal Squamous Cell Carcinoma Model", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 57, no. 7, 1 July 2016 (2016-07-01), US , pages 1105 - 1111, XP093148549, ISSN: 0161-5505, DOI: 10.2967/jnumed.115.167155
SONG IN HO, LEE TAE SUP, PARK YONG SERK, LEE JIN SOOK, LEE BYUNG CHUL, MOON BYUNG SEOK, AN GWANG IL, LEE HAE WON, KIM KWANG IL, LE: "Immuno-PET Imaging and Radioimmunotherapy of 64 Cu-/ 177 Lu-Labeled Anti-EGFR Antibody in Esophageal Squamous Cell Carcinoma Model", THE JOURNAL OF NUCLEAR MEDICINE, SOCIETY OF NUCLEAR MEDICINE, US, vol. 57, no. 7, 1 July 2016 (2016-07-01), US , pages 1105 - 1111, XP093148549, ISSN: 0161-5505, DOI: 10.2967/jnumed.115.167155
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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