Title:
PRODUCTION METHOD OF NOVEL ANTI-HBS IMMUNOGLOBULIN
Document Type and Number:
WIPO Patent Application WO/2022/025129
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a safe and efficacious antibody preparation so as to fundamentally overcome the difficulty that the national self-sufficiency of starting blood for producing anti-HBs human immunoglobulin preparations is still on the way. According to the present invention, the aforesaid problem is solved by providing a recombinant anti-HBs human immunoglobulin preparation that is produced by screening an anti-HBs antigen-specific monoclonal antibody capable of exhibiting a neutralizing activity against HBV from B cells in the peripheral blood circulating in the body of a human individual, said human individual having acquired anti-HBs antibody by HBV vaccination and showing an elevated antibody titer, and then isolating the gene of the antibody.
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Inventors:
SATAKE MASAHIRO (JP)
FURUTA RIKA (JP)
TOYODA CHIZU (JP)
TOBITA RYUTARO (JP)
YASUI TERUHITO (JP)
MINAMITANI TAKEHARU
AKIBA HIROKI (JP)
TSUMOTO KOUHEI (JP)
FURUTA RIKA (JP)
TOYODA CHIZU (JP)
TOBITA RYUTARO (JP)
YASUI TERUHITO (JP)
MINAMITANI TAKEHARU
AKIBA HIROKI (JP)
TSUMOTO KOUHEI (JP)
Application Number:
PCT/JP2021/027933
Publication Date:
February 03, 2022
Filing Date:
July 28, 2021
Export Citation:
Assignee:
JAPAN RED CROSS (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
C07K16/08; A61K39/29; A61K39/395; A61K51/10; A61P31/20; C12N15/13
Foreign References:
| CN105263522A | 2016-01-20 |
Other References:
WANG QIAO; MICHAILIDIS ELEFTHERIOS; YU YINGPU; WANG ZIJUN; HURLEY ARLENE M.; OREN DEENA A.; MAYER CHRISTIAN T.; GAZUMYAN ANNA; LIU: "A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations", CELL HOST & MICROBE, ELSEVIER, NL, vol. 28, no. 2, 5 June 2020 (2020-06-05), NL , pages 335, XP086247146, ISSN: 1931-3128, DOI: 10.1016/j.chom.2020.05.010
HEHLE VERENA, BERETTA MAXIME, BOURGINE MARYLINE, AIT-GOUGHOULTE MALIKA, PLANCHAIS CYRIL, MORISSE SOLEN, VESIN BENJAMIN, LORIN VAL&: "Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 217, no. 10, 5 October 2020 (2020-10-05), US , pages 20200840, XP055836281, ISSN: 0022-1007, DOI: 10.1084/jem.20200840
HEIJTINK R.A., KRUINING J., VAN BERGEN P., DE RAVE S., VAN HATTUM J., SCHUTTEN M., OSTERHAUS A.D.M.E.: "Characterization of a human monoclonal antibody obtained after immunization with plasma vaccine and a booster with recombinant-DNA hepatitis B vaccine", JOURNAL OF MEDICAL VIROLOGY, JOHN WILEY & SONS, INC., US, vol. 66, no. 3, 1 March 2002 (2002-03-01), US , pages 304 - 311, XP055892669, ISSN: 0146-6615, DOI: 10.1002/jmv.2146
HEHLE VERENA, BERETTA MAXIME, BOURGINE MARYLINE, AIT-GOUGHOULTE MALIKA, PLANCHAIS CYRIL, MORISSE SOLEN, VESIN BENJAMIN, LORIN VAL&: "Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, US, vol. 217, no. 10, 5 October 2020 (2020-10-05), US , pages 20200840, XP055836281, ISSN: 0022-1007, DOI: 10.1084/jem.20200840
HEIJTINK R.A., KRUINING J., VAN BERGEN P., DE RAVE S., VAN HATTUM J., SCHUTTEN M., OSTERHAUS A.D.M.E.: "Characterization of a human monoclonal antibody obtained after immunization with plasma vaccine and a booster with recombinant-DNA hepatitis B vaccine", JOURNAL OF MEDICAL VIROLOGY, JOHN WILEY & SONS, INC., US, vol. 66, no. 3, 1 March 2002 (2002-03-01), US , pages 304 - 311, XP055892669, ISSN: 0146-6615, DOI: 10.1002/jmv.2146
Attorney, Agent or Firm:
UCHIYAMA Tsutomu et al. (JP)
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