PRODUCTION METHOD FOR OPTICALLY ACTIVE ALCOHOL COMPOUND

WIPO Patent Application WO/2012/081585

A1

The present invention provides a method for diastereo-selectively and enantioselectively producing an optically active alcohol compound indicated in formula (IIIa), etc., that includes hydrogenation of a carbonyl compound indicated in formula (I) in the presence of a ruthenium compound indicated in formula (II) and a base. (In formula (I) R indicates a C6-C10 aryl group with an unsubstituted or substituted group. Het indicates a 3- to 8-member heterocycle with an unsubstituted or substituted group.) (In formula (II), X and Y each independently indicate a hydrogen group, a tetrahydro borate, etc. Px indicates an optically active or racemate phosphine ligand. n indicates the number of Px and is 1 or 2. A indicates an optically active or racemate dyamine ligand. However, Px and A cannot both be a racemate.) (In formula (IIIa) R and Het have the same meaning as R and Het in formula (I).)

AKASHI MASAYA
INOUE TSUTOMU
OHKUMA TAKESHI
ARAI NORIYOSHI

PCT/JP2011/078816

June 21, 2012

December 13, 2011

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UNIV HOKKAIDO NAT UNIV CORP (JP)
NIPPON SODA CO (JP)
AKASHI MASAYA
INOUE TSUTOMU
OHKUMA TAKESHI
ARAI NORIYOSHI

C07D207/08; C07D211/22; C07D265/30; C07D307/12; C07D409/06; C07B53/00; C07B61/00

WO2000041997A1	2000-07-20
WO2004007506A1	2004-01-22

JP2008515916A	2008-05-15
JP2009515893A	2009-04-16

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 20, 2008, pages 5550 - 5553
JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 22, 2008, pages 9084 - 9093

OGURI Shohei et al. (JP)
Shohei Oguri (JP)

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