Title:
PRODUCTION METHOD FOR OPTICALLY ACTIVE ALCOHOL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/200094
Kind Code:
A1
Abstract:
[Problem] To provide a novel production method for a stereoselective, optically active alcohol compound. [Solution] From the compound represented by formula (3), the optically active alcohol compound represented by formula (8) can be produced with high selectivity and in high yields, and an industrially useful production method and an intermediate of the compound can be provided. (In the formulae, R1 represents a hydrogen atom, a C1—C6 alkyl or a C1—C6 alkyl optionally substituted by R3, or the like; R2 represents a cyano group or -CH2N(R5)R4; and R3 represents a C3—C8 cycloalkyl.)
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Inventors:
KAWANAMI HIROKI (JP)
NISHINO YUKIHIRO (JP)
MURASE SHOTA (JP)
NISHINO YUKIHIRO (JP)
MURASE SHOTA (JP)
Application Number:
PCT/JP2014/065771
Publication Date:
December 18, 2014
Filing Date:
June 13, 2014
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
International Classes:
C07C213/00; B01J31/02; B01J31/22; C07B53/00; C07C217/64; C07C231/18; C07C233/18; C07C253/30; C07C255/37; C07C269/06; C07C271/16; C07D209/48; C07F7/18; C07B61/00
Domestic Patent References:
| WO2009045479A1 | 2009-04-09 |
Foreign References:
| JP2011512321A | 2011-04-21 | |||
| JP2010037332A | 2010-02-18 | |||
| JP2012513966A | 2012-06-21 | |||
| JP2011153076A | 2011-08-11 |
Other References:
MATSUMURA, K. ET AL.: "Chiral Ruthenabicyclic Complexes: Precatalysts for Rapid, Enantioselective, and Wide-Scope Hydrogenation of Ketones", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 133, 2011, pages 10696 - 10699, XP055301019
OHKUMA, T. ET AL.: "Asymmetric Hydrogenation of Alkenyl, Cyclopropyl, and Aryl Ketones. RuCl2 (xylbinap)(1,2-diamine) as a Precatalyst Exhibiting a Wide Scope", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, 1998, pages 13529 - 13530, XP002938992
WANG, F. ET AL.: "Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Hydrophobic Metal-Amido Complexes in Aqueous Micelles and Vesicles", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 70, 2005, pages 9424 - 9429, XP055301507
DEGNI, S. ET AL.: "Highly catalytic enantioselective reduction of aromatic ketones using chiral polymer-supported Corey, Bakshi, and Shibata catalysts", TETRAHEDRON : ASYMMETRY, vol. 15, 2004, pages 1495 - 1499, XP004505356
See also references of EP 3009419A4
OHKUMA, T. ET AL.: "Asymmetric Hydrogenation of Alkenyl, Cyclopropyl, and Aryl Ketones. RuCl2 (xylbinap)(1,2-diamine) as a Precatalyst Exhibiting a Wide Scope", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, 1998, pages 13529 - 13530, XP002938992
WANG, F. ET AL.: "Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Hydrophobic Metal-Amido Complexes in Aqueous Micelles and Vesicles", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 70, 2005, pages 9424 - 9429, XP055301507
DEGNI, S. ET AL.: "Highly catalytic enantioselective reduction of aromatic ketones using chiral polymer-supported Corey, Bakshi, and Shibata catalysts", TETRAHEDRON : ASYMMETRY, vol. 15, 2004, pages 1495 - 1499, XP004505356
See also references of EP 3009419A4
Attorney, Agent or Firm:
HANABUSA, Tsuneo et al. (JP)
Sepal Tsuneo (JP)
Sepal Tsuneo (JP)
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