Title:
PRODUCTION METHOD FOR PROLIFERATIVE MYELOID CELLS THAT CONSTITUTIVELY PRODUCE IL-12P70
Document Type and Number:
WIPO Patent Application WO/2023/229013
Kind Code:
A1
Abstract:
Provided is a production method for proliferative myeloid cells that constitutively produce IL-12p70, the method comprising: (1) a step for introducing a nucleic acid encoding c-MYC into myeloid cells; (2) a step for culturing the cells obtained in step (1) in the presence of GM-CSF and M-CSF; and (3) a step for introducing a nucleic acid encoding an IL-12p35 subunit and a nucleic acid encoding an IL-12p40 subunit into the cells obtained in step (2).
Inventors:
UEMURA YASUSHI (JP)
FUKUDA KYOKO (JP)
FUKUDA KYOKO (JP)
Application Number:
PCT/JP2023/019528
Publication Date:
November 30, 2023
Filing Date:
May 25, 2023
Export Citation:
Assignee:
BEIJING TIANYIFANG BIO DEV CO LTD (CN)
NAT CANCER CT (JP)
NAT CANCER CT (JP)
International Classes:
A61K45/00; A61K35/15; A61K35/545; A61P35/00; A61P37/04; A61P43/00; C12N5/0735; C12N5/078; C12N5/0783; C12N5/0789; C12N5/10; C12N15/09; C12N15/12; C12N15/24
Domestic Patent References:
| WO2012043651A1 | 2012-04-05 | |||
| WO2021230304A1 | 2021-11-18 |
Foreign References:
| JP2015501840A | 2015-01-19 | |||
| JP2020520640A | 2020-07-16 | |||
| JP2021526838A | 2021-10-11 |
Other References:
BIAN ZHEN, SHI LEI, KIDDER KOBY, ZEN KE, GARNETT-BENSON CHARLIE, LIU YUAN: "Intratumoral SIRPĪ±-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy", NATURE COMMUNICATIONS, vol. 12, no. 1, pages 1 - 16, XP093067948, DOI: 10.1038/s41467-021-23442-z
Attorney, Agent or Firm:
OKUYAMA, Shoichi et al. (JP)
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