Title:
PRODUCTION METHOD FOR PURIFIED DICHLOROACETIC ACID
Document Type and Number:
WIPO Patent Application WO/2023/054350
Kind Code:
A1
Abstract:
The present invention provides a production method for purified dichloroacetic acid and an efficient production method for nucleic acid molecules using same. Specifically, the present invention provides: a production method for purified dichloroacetic acid in which the molar ratio of formaldehyde to dichloroacetic acid is 81×10-5 or lower and the molar ratio of dichloroacetic anhydride to dichloroacetic acid is 20×10-5 or lower, wherein dichloroacetic acid having a formaldehyde and/or dichloroacetic anhydride content higher than the aforementioned ratios is brought into contact with at least one compound having a lower boiling point than dichloroacetic acid selected from the group consisting of aliphatic alcohols, aliphatic amines, and water, and a fraction including an aprotic inert solvent having a boiling point lower than that of dichloroacetic acid is distilled from the produced mixed liquid in the presence of the solvent; and a production method for nucleic acid molecules in which the purified dichloroacetic acid is used as a deprotection agent.
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Inventors:
KANO TOSHIFUMI (JP)
TANAKA YUKI (JP)
KAWAI HAYATO (JP)
TANAKA YUKI (JP)
KAWAI HAYATO (JP)
Application Number:
PCT/JP2022/035920
Publication Date:
April 06, 2023
Filing Date:
September 27, 2022
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07C51/487; C07C51/493; C07C53/16; C07C231/02; C07C233/05; C07H21/04; C12N15/11
Domestic Patent References:
| WO1999043694A1 | 1999-09-02 | |||
| WO2021193954A1 | 2021-09-30 | |||
| WO2022009959A1 | 2022-01-13 |
Foreign References:
| CN112209817A | 2021-01-12 | |||
| JPS5058014A | 1975-05-20 | |||
| JPS4730165B1 | ||||
| JP2015516960A | 2015-06-18 |
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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