Title:
PRODUCTION METHOD FOR RADIOHALOGEN-LABELED COMPOUND AND PRODUCTION METHOD FOR RAIDOPHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2018/235535
Kind Code:
A1
Abstract:
Provided is a production method for a radiohalogen-labeled compound, the method comprising: a step in which a radiohalogen-labeled precursor compound (S-L) including a leaving group (L) capable of nucleophilic substitution with a radiohalide ion (X-) is subjected to a radiohalogenation reaction to obtain a reaction mixture RM1 which contains both the radiohalogen-labeled precursor compound (S-L) and a reaction product (S-X) resulting from the radiohalogenation reaction; a step in which the reaction mixture RM1 is mixed with a polyvalent acid or a salt thereof to obtain a reaction mixture RM2; and a step in which the reaction product (S-X) is purified from the reaction mixture RM2 by a solid-phase extraction method.
Inventors:
OKUMURA YUKI (JP)
NAKAMURA DAISAKU (JP)
KIRIU MASATO (JP)
ICHIKAWA HIROAKI (JP)
TONOYA GOTA (JP)
SUGIMOTO NAOMI (JP)
NAKAMURA DAISAKU (JP)
KIRIU MASATO (JP)
ICHIKAWA HIROAKI (JP)
TONOYA GOTA (JP)
SUGIMOTO NAOMI (JP)
Application Number:
PCT/JP2018/020403
Publication Date:
December 27, 2018
Filing Date:
May 28, 2018
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
International Classes:
C07D403/14; A61K51/04; C07D233/91; C07B59/00
Domestic Patent References:
| WO2009127372A1 | 2009-10-22 | |||
| WO2011006610A1 | 2011-01-20 | |||
| WO2013042668A1 | 2013-03-28 | |||
| WO2015199205A1 | 2015-12-30 |
Foreign References:
| JP2015504443A | 2015-02-12 | |||
| JP2008515793A | 2008-05-15 | |||
| JP2015081242A | 2015-04-27 | |||
| JP2017081847A | 2017-05-18 | |||
| JP2017052713A | 2017-03-16 | |||
| JP2017122981A | 2017-07-13 |
Other References:
"Greene's Protective Groups in Organic Synthesis", 27 October 2014, JOHN WILEY SONS INC
See also references of EP 3643710A4
See also references of EP 3643710A4
Attorney, Agent or Firm:
IDE Masatake (JP)
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