Title:
PRODUCTION METHOD FOR SYNTHETIC INTERMEDIATE OF MONOCYCLIC PYRIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/032872
Kind Code:
A1
Abstract:
Provided is a production method that enables synthesis of key intermediates (a compound (2i) or a salt thereof and a compound (1g)) for producing E7090, which is useful as an FGFR inhibitor, in higher yields and with higher working efficiency.
Inventors:
NAGAI MITSUO (JP)
FUKUYAMA TAKASHI (JP)
KAMADA YASUAKI (JP)
NIIJIMA JUN (JP)
KURODA HIROFUMI (JP)
KAROJI YUKI (JP)
MURAKAMI KEIICHI (JP)
OMORI MASAYUKI (JP)
MIYASHITA YUSUKE (JP)
KAMADA ATSUSHI (JP)
MATSUDA MASAAKI (JP)
FUKUYAMA TAKASHI (JP)
KAMADA YASUAKI (JP)
NIIJIMA JUN (JP)
KURODA HIROFUMI (JP)
KAROJI YUKI (JP)
MURAKAMI KEIICHI (JP)
OMORI MASAYUKI (JP)
MIYASHITA YUSUKE (JP)
KAMADA ATSUSHI (JP)
MATSUDA MASAAKI (JP)
Application Number:
PCT/JP2022/032309
Publication Date:
March 09, 2023
Filing Date:
August 29, 2022
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
C07D401/12; C07D209/32
Domestic Patent References:
| WO2014129477A1 | 2014-08-28 | |||
| WO2016027781A1 | 2016-02-25 | |||
| WO2009117421A2 | 2009-09-24 | |||
| WO2004002410A2 | 2004-01-08 | |||
| WO2014129477A1 | 2014-08-28 | |||
| WO2016027781A1 | 2016-02-25 |
Other References:
YIN JINGJUN ET AL: "A general and efficient 2-amination of pyridines and quinolines", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 72, no. 12, 1 June 2007 (2007-06-01), pages 4554 - 4557, XP002514944, ISSN: 0022-3263, DOI: 10.1021/JO070189Y
IMAKURA Y, ET AL.: "REGIOSELECTIVE CLEAVAGE REACTION OF THE AROMATIC METHYLENEDIOXY RING. V. CLEAVAGE WITH SODIUM ALKOXIDES-ALCOHOLS, POTASSIUM TERT-BUTOXIDE-ALCOHOLS, DIMSYL ANION-METHYL ALCOHOL, METALLIC SODIUM-ALCOHOLS, AND SODIUM CYANIDE IN DIPOLAR APROTIC SOLVENTS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 40, no. 07, 1 July 1992 (1992-07-01), JP , pages 1691 - 1696, XP001148863, ISSN: 0009-2363
IMAKURA Y, ET AL.: "REGIOSELECTIVE CLEAVAGE REACTION OF THE AROMATIC METHYLENEDIOXY RING. V. CLEAVAGE WITH SODIUM ALKOXIDES-ALCOHOLS, POTASSIUM TERT-BUTOXIDE-ALCOHOLS, DIMSYL ANION-METHYL ALCOHOL, METALLIC SODIUM-ALCOHOLS, AND SODIUM CYANIDE IN DIPOLAR APROTIC SOLVENTS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 40, no. 07, 1 July 1992 (1992-07-01), JP , pages 1691 - 1696, XP001148863, ISSN: 0009-2363
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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