Title:
A PRODUCTION PROCESS FOR 16-DEHYDROPREGNENONEOL AND ITS ANALOGS
Document Type and Number:
WIPO Patent Application WO/2005/007668
Kind Code:
A1
Abstract:
A production process for 16-dehydropregnenoneol and its analogs is provided. In which, the psudosapogenin decomposed from steroid sapogenin, with or without purification, reacts with hydrogen peroxide in the organic solvent under the presence of metal catalysts and acid. The crude react product is directly subjected to alkali elimination hydrolysis and results in 16-dehydropregnenoneol or its analogs and 4R(or S)-methy1-4-hydroxyl-pentanoate. This process enhanced the availability of steroid sapogenin, avoided the contamination of the metal chromic compound consisted in the prior arts, and further enhanced the yield and is more suitable for production requirements.
Inventors:
TIAN WEISHENG (CN)
XU XIN (CN)
LIU SHANSHAN (CN)
SHEN JUNWEI (CN)
WU XIUJING (CN)
XU XIN (CN)
LIU SHANSHAN (CN)
SHEN JUNWEI (CN)
WU XIUJING (CN)
Application Number:
PCT/CN2004/000636
Publication Date:
January 27, 2005
Filing Date:
June 14, 2004
Export Citation:
Assignee:
SHANHGHAI INST OF ORGANIC CHEM (CN)
TIAN WEISHENG (CN)
XU XIN (CN)
LIU SHANSHAN (CN)
SHEN JUNWEI (CN)
WU XIUJING (CN)
TIAN WEISHENG (CN)
XU XIN (CN)
LIU SHANSHAN (CN)
SHEN JUNWEI (CN)
WU XIUJING (CN)
International Classes:
C07J7/00; C07J71/00; (IPC1-7): C07J7/00; C07J71/00
Foreign References:
| CN1341603A | 2002-03-27 | |||
| CN1061985C | 2001-02-14 | |||
| CN1299821A | 2001-06-20 | |||
| CN1055930C | 2000-08-30 | |||
| US4753932A | 1988-06-28 |
Other References:
HAN G. ET AL.: "Development of total synthesis of contraceptive steroid drugs in China", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 31, no. 5, 2000, pages 231 - 236
Attorney, Agent or Firm:
SHANGHAI KAIJI INTELLECTUAL PROPERTY AGENT CO., LTD. (188 Nandandong Road, Shanghai 0, CN)
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