Title:
PRODUCTIVITY-ENHANCED ANTIBODY AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2020/080715
Kind Code:
A1
Abstract:
The present invention pertains to a method for producing a productivity-enhanced antibody, and more specifically, to a method in which the productivity of an antibody can be significantly improved while maintaining the titer thereof through the O-linked glycosylation of at least one hydroxyamino acid included in the light chain of the antibody.
Inventors:
KIM JOO YOUNG (KR)
LEE JINU (KR)
KIM HYE YEON (KR)
LEE JINU (KR)
KIM HYE YEON (KR)
Application Number:
PCT/KR2019/013008
Publication Date:
April 23, 2020
Filing Date:
October 04, 2019
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
C07K16/28; A61K39/00; C12N5/16
Domestic Patent References:
| WO2010128145A1 | 2010-11-11 | |||
| WO2005103081A2 | 2005-11-03 | |||
| WO2004035607A2 | 2004-04-29 | |||
| WO2004056312A2 | 2004-07-08 | |||
| WO2006121168A1 | 2006-11-16 | |||
| WO2013014668A1 | 2013-01-31 | |||
| WO2009101611A1 | 2009-08-20 |
Foreign References:
| US5736137A | 1998-04-07 | |||
| US5776456A | 1998-07-07 | |||
| EP2000149B1 | 2009-05-13 | |||
| US8008449B2 | 2011-08-30 | |||
| US8686119B2 | 2014-04-01 | |||
| EP2015054862W | 2015-03-09 |
Other References:
MARTINEZ, T.: "Characterization of a novel modification on IgG2 light chain: Evidence for the presence of 0-linked mannosylation", JOURNAL OF CHROMATOGRAPHY A, 2007, pages 183 - 187, XP022125989
HASTINGS, N. B.: "Inhibition of O-GlcNAcase leads to elevation of 0-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice", MOLECULAR NEURODEGENERATION, 2017, XP055702163
VALLIERE-DOUGLASS, J. F.: "0-fucosytation of an antibody light chain: characterization of a modification occurring on an IgGl molecule", GLYCOBIOLOGY, 2009, pages 144 - 152 144-145, 147-148, XP055702159
KIM, HYE YEON: "Improvement the rituximab production by O-G1cNAcylation using Thiamet G", MASTER'S THESIS, YONSEI UNIVERSITY, August 2019 (2019-08-01), pages 1 - 53, XP055799705
VALENTINE ET AL., J. BIOL. CHEM., vol. 264, no. 19, 1989, pages 11282 - 11287
EINFELD ET AL., EMBO J., vol. 7, no. 3, 1988, pages 711 - 717
ANDERSON ET AL., BLOOD, vol. 63, no. 6, 1984, pages 1424 - 1433
TEDDER ET AL., J. IMMUNOL., vol. 135, no. 2, 1985, pages 973 - 979
TEDDER ET AL., J. CELL. BIOCHEM., vol. 14D, 1990, pages 195
REFF ET AL., BLOOD, vol. 83, no. 2, 1994, pages 435 - 445
CRAGG, M. S. ET AL., BLOOD, vol. 103, 2004, pages 2738 - 2743
CRAGG, M. S. ET AL., BLOOD, vol. 101, 2003, pages 1045 - 1052
WANG ET AL., CANCER IMMUNOL RES., vol. 2, 2014, pages 846 - 56
TOPALIAN, S. L. ET AL., N ENGL J MED, vol. 366, 2012, pages 2443 - 2454
TOPALIAN, S. L. ET AL., CURRENT OPINION IN IMMUNOLOGY, vol. 24, 2012, pages 207 - 212
TOPALIAN, S. L. ET AL., J CLIN ONCOL, vol. 31, 2013, pages 4199 - 4206
HAMID, O. ET AL., N ENGL J MED, vol. 369, 2013, pages 134 - 144
BERGER, R. ET AL., CLINICAL CANCER RESEARCH, vol. 14, 2008, pages 3044 - 3051
BMC BIOINFORMATICS, vol. 12, 6 April 2011 (2011-04-06), pages 91
HASTINGS, N. B.: "Inhibition of O-GlcNAcase leads to elevation of 0-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice", MOLECULAR NEURODEGENERATION, 2017, XP055702163
VALLIERE-DOUGLASS, J. F.: "0-fucosytation of an antibody light chain: characterization of a modification occurring on an IgGl molecule", GLYCOBIOLOGY, 2009, pages 144 - 152 144-145, 147-148, XP055702159
KIM, HYE YEON: "Improvement the rituximab production by O-G1cNAcylation using Thiamet G", MASTER'S THESIS, YONSEI UNIVERSITY, August 2019 (2019-08-01), pages 1 - 53, XP055799705
VALENTINE ET AL., J. BIOL. CHEM., vol. 264, no. 19, 1989, pages 11282 - 11287
EINFELD ET AL., EMBO J., vol. 7, no. 3, 1988, pages 711 - 717
ANDERSON ET AL., BLOOD, vol. 63, no. 6, 1984, pages 1424 - 1433
TEDDER ET AL., J. IMMUNOL., vol. 135, no. 2, 1985, pages 973 - 979
TEDDER ET AL., J. CELL. BIOCHEM., vol. 14D, 1990, pages 195
REFF ET AL., BLOOD, vol. 83, no. 2, 1994, pages 435 - 445
CRAGG, M. S. ET AL., BLOOD, vol. 103, 2004, pages 2738 - 2743
CRAGG, M. S. ET AL., BLOOD, vol. 101, 2003, pages 1045 - 1052
WANG ET AL., CANCER IMMUNOL RES., vol. 2, 2014, pages 846 - 56
TOPALIAN, S. L. ET AL., N ENGL J MED, vol. 366, 2012, pages 2443 - 2454
TOPALIAN, S. L. ET AL., CURRENT OPINION IN IMMUNOLOGY, vol. 24, 2012, pages 207 - 212
TOPALIAN, S. L. ET AL., J CLIN ONCOL, vol. 31, 2013, pages 4199 - 4206
HAMID, O. ET AL., N ENGL J MED, vol. 369, 2013, pages 134 - 144
BERGER, R. ET AL., CLINICAL CANCER RESEARCH, vol. 14, 2008, pages 3044 - 3051
BMC BIOINFORMATICS, vol. 12, 6 April 2011 (2011-04-06), pages 91
Attorney, Agent or Firm:
LEE, Jae Young (KR)
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